Mechanical contribution of lamellar and interlamellar elastin along the mouse aorta

Journal of Biomechanics
T E ClarkR E Shadwick

Abstract

The mechanical properties of aortic elastin vary regionally, but the microstructural basis for this variation is unknown. This study was designed to identify the relative contributions of lamellar and interlamellar elastin to circumferential load bearing in the mouse thoracic and abdominal aortas. Forces developed in uniaxial tests of samples of fresh and autoclaved aorta were correlated with elastin content and morphology obtained from histology and multiphoton laser scanning microscopy. Autoclaving should render much of the interlamellar elastin mechanically incompetent. In autoclaved tissue force per unit sample width correlated with lamellar elastin content (P≪0.001) but not total elastin content. In fresh tissue at low strain where elastin dominates the mechanical response, forces were higher than in the autoclaved tissue, but force did not correlate with total elastin content. Therefore although interlamellar elastin likely contributed to the stiffness in the fresh aorta, its contribution appeared not in proportion to its quantity. In both fresh and autoclaved tissue, elastin stiffness consistently decreased along the abdominal aorta, a key area for aneurysm development, and this difference could not be fully accounted fo...Continue Reading

References

Jul 5, 1990·Biopolymers·M A Lillie, J M Gosline
Jan 1, 1967·Circulation Research·H Wolinsky, S Glagov
Jan 4, 1998·Journal of Biomechanical Engineering·S E GreenwaldJ J Meister
Jun 27, 1998·Connective Tissue Research·M A LillieJ M Gosline
May 16, 2002·Biopolymers·M A Lillie, J M Gosline
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·X GuoG S Kassab
May 1, 1964·Circulation Research·H WOLINSKY, S GLAGOV
Jun 1, 1960·Journal of Ultrastructure Research·D C PEASE, W J PAULE
Nov 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Xiaomei Guo, Ghassan S Kassab
Sep 30, 2004·Biophysical Journal·Aikaterini ZoumiBruce J Tromberg
Jan 1, 1994·Connective Tissue Research·M A LillieJ M Gosline
Oct 13, 2006·Journal of Vascular Research·M A Lillie, J M Gosline
Dec 19, 2006·Journal of Biomechanics·M A Lillie, J M Gosline
Jan 24, 2007·Biomaterials·M A Lillie, J M Gosline
Feb 6, 2008·Matrix Biology : Journal of the International Society for Matrix Biology·Mary K O'ConnellCharles A Taylor
Apr 8, 2009·Annals of Biomedical Engineering·J F EberthJ D Humphrey
Jun 2, 2009·Annals of Biomedical Engineering·Yu Zou, Yanhang Zhang
Jul 9, 2009·Physiological Reviews·Jessica E Wagenseil, Robert P Mecham
Dec 2, 2009·Annals of Biomedical Engineering·E Jane Walter, Sarah M Wells
Jul 9, 2010·Annals of Biomedical Engineering·William WanRudolph L Gleason
Oct 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Craig J GoergenJoan M Greve
Feb 12, 2013·Biomechanics and Modeling in Mechanobiology·Vaibhav AgrawalNamrata Gundiah

❮ Previous
Next ❯

Citations

Aug 22, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Hadi Taghizadeh, Mohammad Tafazzoli-Shadpour
Aug 15, 2018·The Journal of Experimental Biology·Robert E ShadwickJohn F Steffensen
May 22, 2019·Applied Bionics and Biomechanics·Rebecca Lownes UrbanoAlisa Morss Clyne
Sep 8, 2019·Matrix Biology : Journal of the International Society for Matrix Biology·Wassim FhayliGilles Faury
Feb 16, 2021·Experimental Mechanics·R WangY Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.