Mechanical Dyssynchrony by Tissue Doppler Cross-Correlation is Associated with Risk for Complex Ventricular Arrhythmias after Cardiac Resynchronization Therapy

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Bhupendar TayalPeter Sogaard

Abstract

Tissue Doppler cross-correlation analysis has been shown to be associated with long-term survival after cardiac resynchronization defibrillator therapy (CRT-D). Its association with ventricular arrhythmia (VA) is unknown. From two centers 151 CRT-D patients (New York Heart Association functional classes II-IV, ejection fraction ≤ 35%, and QRS duration ≥ 120 msec) were prospectively included. Tissue Doppler cross-correlation analysis of myocardial acceleration curves from the basal segments in the apical views both at baseline and 6 months after CRT-D implantation was performed. Patients were divided into four subgroups on the basis of dyssynchrony at baseline and follow-up after CRT-D. Outcome events were predefined as appropriate antitachycardia pacing, shock, or death over 2 years. Mechanical dyssynchrony was present in 97 patients (64%) at baseline. At follow-up, 42 of these 97 patients (43%) had persistent dyssynchrony. Furthermore, among 54 patients with no dyssynchrony at baseline, 15 (28%) had onset of new dyssynchrony after CRT-D. In comparison with the group with reduced dyssynchrony, patients with persistent dyssynchrony after CRT-D were associated with a substantially increased risk for VA (hazard ratio [HR], 4.4; 95...Continue Reading

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Citations

Nov 26, 2015·Cardiac Electrophysiology Clinics·John Gorcsan, Bhupendar Tayal
Sep 28, 2017·European Heart Journal Cardiovascular Imaging·Elena GalliErwan Donal
May 28, 2019·European Heart Journal Cardiovascular Imaging·Pieter van der BijlJeroen J Bax
Nov 27, 2018·Aging·Bhupendar Tayal, Peter Sogaard
Sep 10, 2020·Pacing and Clinical Electrophysiology : PACE·Christoffer PolcwiartekBrett D Atwater
Oct 12, 2019·Cardiovascular Ultrasound·Tomas ZarembaPeter Søgaard
Mar 5, 2021·Frontiers in Cardiovascular Medicine·Bhupendar TayalDipan J Shah
May 16, 2018·JACC. Clinical Electrophysiology·Angelo Auricchio, Frits W Prinzen

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