PMID: 11324963Apr 28, 2001Paper

Mechanical haemolysis in shock wave lithotripsy (SWL): II. In vitro cell lysis due to shear

Physics in Medicine and Biology
M LokhandwallaB Sturtevant

Abstract

In this work we report injury to isolated red blood cells (RBCs) due to focused shock waves in a cavitation-free environment. The lithotripter-generated shock wave was refocused by a parabolic reflector. This refocused wave field had a tighter focus (smaller beam width and a higher amplitude) than the lithotripter wave field, as characterized by a membrane hydrophone. Cavitation was eliminated by applying overpressure to the fluid. A novel passive cavitation detector (HP-PCD) operating at high overpressure (up to 7 MPa) was used to measure acoustic emission due to bubble activity. The typical 'double-bang' emission measured in the lithotripter free-field was replaced by a continuum of weak signals when the fluid was enclosed in a pressure chamber. No acoustic emissions were measured above an overpressure of 5.5 MPa. Aluminium foils were used to study shock wave damage and had distinct deformation features corresponding to exposure conditions, i.e. pitting and denting accompanied by wrinkling. Pitting was eliminated by high overpressure and so was due to cavitation bubble collapse, whereas denting and wrinkling were caused by the reflected shock wave refocused by the parabolic reflector. RBCs suspended in phosphate-buffered sali...Continue Reading

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Citations

Mar 5, 2004·Ultrasound in Medicine & Biology·Sandra L PoliachikLawrence A Crum
Jun 7, 2005·Ultrasound in Medicine & Biology·M AroraC D Ohl
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