Mechanical, histologic, and biochemical effects of canine rectal formalin instillation

Diseases of the Colon and Rectum
J A MyersT J Saclarides

Abstract

Instillation of 4 percent formalin effectively treats radiation hemorrhagic proctitis; however, little is known regarding its side effects. The study contained herein was undertaken to determine rectal compliance and collagen content, mucosal and vascular histologic changes, and kinetics of formalin absorption following instillation. Fifteen mongrel dogs (50-60 pounds) were randomized into five experimental groups according to time elapsed from formalin treatment: control, acute, one week, two weeks, and four weeks. Formalin was instilled in 30-ml aliquots to a total volume of 400 ml. Rectal compliance (closed manometry system) was assessed pre-formalin and post-formalin at the designated time interval. Serum formalin metabolites were determined at time 0, 0.5, 1, and 3 hours. A segment of rectal wall was analyzed for collagen content, mucosal injury, and blood vessel density. Serum formalin levels peaked within 30 minutes, returning to normal by 3 hours. With the exception of one dog, toxic levels were not reached at any time during the study. No dogs experienced sepsis, fever, or altered gastrointestinal function. Acute and one-week dogs showed mild diffuse proctitis and mucosal slough, which healed within two weeks. Rectal c...Continue Reading

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Citations

Dec 14, 2001·Diseases of the Colon and Rectum·J J Tjandra, S Sengupta
Jun 12, 1999·American Journal of Surgery·S F CounterM J Hart
Sep 13, 2001·Alimentary Pharmacology & Therapeutics·J J HongE D Ehrenpreis
Jun 5, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R C ChautemsB Roche
Apr 25, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F L VyasS R Banerjee Jesudason
Feb 24, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·V P Nelamangala RamakrishnaiahS Krishnamachari
Sep 7, 2002·Annals of the Royal College of Surgeons of England·M A Ismail, M A Qureshi
Feb 28, 2007·Yonsei Medical Journal·Sun-Il LeeSeung-Kook Sohn
Feb 15, 2005·World Journal of Surgical Oncology·Lazar B DavidovicStevo N Duvnjak
Dec 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Eero I T SihvoJarmo A Salo
Jul 4, 2013·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·P L EriksenA Tøttrup
Jul 22, 2005·Surgical Innovation·Shingo TsujinakaSteven D Wexner
Jan 12, 2019·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·M S De Robles, C J Young
Aug 20, 2009·Diseases of the Colon and Rectum·Purnal PatelAlasdair McKendrick
Apr 4, 2015·World Journal of Gastroenterology : WJG·Teng-Hui MaLei Wang

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