Mechanical, Histological, and Scanning Electron Microscopy Study of the Effect of Mixed-Acid and Heat Treatment on Additive-Manufactured Titanium Plates on Bonding to the Bone Surface

Materials
Naoko ImagawaTakaaki Ueno

Abstract

The additive manufacturing (AM) technique has attracted attention as one of the fully customizable medical material technologies. In addition, the development of new surface treatments has been investigated to improve the osteogenic ability of the AM titanium (Ti) plate. The purpose of this study was to evaluate the osteogenic activity of the AM Ti with mixed-acid and heat (MAH) treatment. Fully customized AM Ti plates were created with a curvature suitable for rat calvarial bone, and they were examined in a group implanted with the MAH-treated Ti in comparison with the untreated (UN) group. The AM Ti plates were fixed to the surface of rat calvarial bone, followed by extraction of the calvarial bone 1, 4, 8, and 12 weeks after implantation. The bonding between the bone and Ti was evaluated mechanically. In addition, AM Ti plates removed from the bone were examined histologically by electron microscopy and Villanueva-Goldner stain. The mechanical evaluation showed significantly stronger bone-bonding in the MAH group than in the UN group. In addition, active bone formation was seen histologically in the MAH group. Therefore, these findings indicate that MAH resulted in rapid and strong bonding between cortical bone and Ti.

References

Jun 1, 1990·Journal of Biomedical Materials Research·T KokuboT Yamamuro
Jul 1, 1989·Archives of Otolaryngology--head & Neck Surgery·A KomisarE Danziger
Sep 1, 1983·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·G A CobettoR D Zallen
Jan 30, 2002·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Takahiko ShibaharaRyou Takaki
Feb 2, 2006·Biomaterials·Tadashi Kokubo, Hiroaki Takadama
Jan 6, 2009·The Journal of Bone and Joint Surgery. American Volume·Kevin J BozicDaniel J Berry
May 7, 2010·Journal of the Royal Society, Interface·Tadashi KokuboTakashi Nakamura
Aug 13, 2011·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Yoshimitsu Okazaki
Sep 6, 2012·Clinical Orthopaedics and Related Research·Kwok Chuen Wong, Shekhar Madhukar Kumta
Sep 6, 2012·Journal of Materials Science. Materials in Medicine·Toshiyuki KawaiTadashi Kokubo
Mar 28, 2013·Journal of Materials Science. Materials in Medicine·Toshiyuki KawaiShuichi Matsuda
Dec 7, 2013·Journal of Bone and Mineral Metabolism·Masako TsukanakaHaruhiko Akiyama
Feb 13, 2014·PloS One·Toshiyuki KawaiShuichi Matsuda
Jul 18, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Naruto OtawaTomiharu Matsushita
Nov 26, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Tomoki SumidaYoshihide Mori
Aug 2, 2016·BioMed Research International·Ralf SmeetsTobias Ebker
May 1, 2017·The Journal of Arthroplasty·Ronald E DelanoisMichael A Mont
Oct 3, 2017·Journal of Applied Biomaterials & Functional Materials·Francesco TrevisanDiego Manfredi
Apr 21, 2018·Materials·Chengyang DengPengyue Wu
Jan 27, 2019·Journal of Biomedical Materials Research. Part a·Tadashi Kokubo, Seiji Yamaguchi
Sep 2, 2019·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Akram Abdo AlmansooriJong-Ho Lee
Nov 26, 2019·Materials Science & Engineering. C, Materials for Biological Applications·F BartolomeuF S Silva

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopy
X-ray
scanning electron microscopy

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.