Mechanical influences on cardiovascular differentiation and disease modeling

Experimental Cell Research
Evan L Teng, Adam J Engler

Abstract

Tissues are continuously exposed to forces in vivo, whether from fluid pressure in an artery from our blood or compressive forces on joints from our body weight. The forces that cells are exposed to arise almost immediately after conception; it is therefore important to understand how forces shape stem cell differentiation into lineage committed cells, how they help organize cells into tissues, and how forces can cause or exacerbate disease. No tissue is exempt, but cardiovascular tissues in particular are exposed to these forces. While animal models have been used extensively in the past, there is growing recognition of their limitations when modeling disease complexity or human genetics. In this mini review, we summarize current understanding of the mechanical influences on the differentiation of cardiovascular progeny, how the transduction of forces influence the onset of disease, and how engineering approaches applied to this problem have yielded systems that create mature-like human tissues in vitro in which to assess the impact of disease on cell function.

References

Apr 16, 1999·Science·L E NiklasonR Langer
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·G Garcia-CardeñaM A Gimbrone
Feb 5, 2004·Annals of Biomedical Engineering·Evan A ZamirLarry A Taber
Apr 7, 2004·Circulation·Norbert FreyJoseph A Hill
Jul 7, 2007·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·S S M RensenG J J M van Eys
Jul 1, 2008·Biophysical Journal·Jeffrey G JacotJeffrey H Omens
Jun 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Wesley R LegantChristopher S Chen
Jun 27, 2009·Science·Dennis E DischerPeter W Zandstra
Dec 3, 2009·Cell Stem Cell·Krishanu Saha, Rudolf Jaenisch
Jun 22, 2010·Cell Communication & Adhesion·Kelly C ClauseKimimasa Tobita
Jul 20, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Erik BlaauwGer J van der Vusse
Jun 17, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Christopher P Mack
Oct 27, 2011·Expert Review of Medical Devices·Junmin Zhu, Roger E Marchant
Dec 8, 2011·Nature Medicine·Gustavo TiscorniaJuan Carlos Izpisúa Belmonte
Apr 21, 2012·Science Translational Medicine·Ning SunJoseph C Wu
Jun 26, 2012·Nature Biotechnology·Ethan S LippmannEric V Shusta
Jun 30, 2012·American Journal of Physiology. Cell Physiology·Syotaro ObiTakayuki Asahara
Aug 7, 2012·Journal of Biomedical Materials Research. Part a·Olufunmilayo AdebayoMarsha W Rolle
Dec 1, 2012·Science·Frank Soldner, Rudolf Jaenisch
Jun 7, 2014·Circulation Research·Jacob Fog BentzonErling Falk
Oct 26, 2014·Cell and Tissue Research·Martina CaloreAlessandra Rampazzo
Oct 31, 2014·Nature Reviews. Molecular Cell Biology·Jay D HumphreyMartin A Schwartz
Mar 10, 2015·Scientific Reports·Anurag MathurKevin E Healy
Jul 15, 2015·Nature Communications·Zhen MaKevin E Healy
Jul 28, 2015·Advanced Drug Delivery Reviews·Abdul Jalil Rufaihah, Dror Seliktar
Jul 28, 2015·Nature Cell Biology·Christoph PatschChad A Cowan
Sep 18, 2015·Journal of Biomedical Materials Research. Part a·Yahya ElsayedPaul Tomlins
Mar 2, 2016·The Journal of Clinical Investigation·Nicolas BaeyensMartin A Schwartz
Oct 22, 2016·Biomaterials·Christopher P JackmanNenad Bursac
May 22, 2017·Biochemical and Biophysical Research Communications·Akankshya ShradhanjaliJung Yul Lim
Aug 5, 2017·Fluids and Barriers of the CNS·Jackson G DeStefanoPeter C Searson

❮ Previous
Next ❯

Citations

Nov 6, 2020·Biomaterials Science·Kamol DeyLuciana Sartore

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

The Journal of Hand Surgery
S W Wolfe
Frontiers in Bioengineering and Biotechnology
Claudia WittkowskeCecile M Perrault
© 2022 Meta ULC. All rights reserved