Mechanical insights into the regulation of programmed cell death by p53 via mitochondria

Biochimica Et Biophysica Acta. Molecular Cell Research
Kohji Yamada, Kiyotsugu Yoshida

Abstract

All organisms end with their death, and many parts of cells die through intrinsic suicide machineries in response to diverse stimuli. These intrinsic cell death pathways are often termed as programmed cell deaths (PCDs), and are critical for organism development, tissue homeostasis and various diseases. Recent evidence has revealed that most of PCDs involve a tumor suppressor p53 and components of the intra-mitochondria. Furthermore, the movement and positioning of p53 in cells affect the induction of each PCD pathway. Here we provide a comprehensive review on p53-related PCD mechanisms via the mitochondria, namely classical apoptosis, non-classical apoptosis, autophagic cell death, ferroptosis, necroptosis. In addition, we discuss the roles of p53 in each PCD pathway by focusing its altered intracellular localization in response to diverse cellular stresses.

Citations

Mar 28, 2020·Biomolecules·Su-Been LeeHo-Shik Kim
Jun 17, 2020·Frontiers in Pharmacology·Qing-Xia GanQin-Wan Huang
Jan 14, 2021·International Journal of Biological Macromolecules·Marjan TalebiSaeed Samarghandian
Jul 30, 2019·Diagnostic Microbiology and Infectious Disease·Ramon R P P B de MenezesAlice M C Martins
Dec 11, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Baoyi LiuZhouwei Wu
Dec 4, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Aixin OuZaiming Lu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis