Mechanical loading of in situ chondrocytes in lapine retropatellar cartilage after anterior cruciate ligament transection.

Journal of the Royal Society, Interface
Sang-Kuy HanWalter Herzog

Abstract

The aims of this study were (i) to quantify chondrocyte mechanics in fully intact articular cartilage attached to its native bone and (ii) to compare the chondrocyte mechanics for cells in healthy and early osteoarthritis (OA) tissue. We hypothesized that cells in the healthy tissue would deform less for given articular surface pressures than cells in the early OA tissue because of a loss of matrix integrity in early OA and the associated loss of structural integrity that is thought to protect chondrocytes. Chondrocyte dynamics were quantified by measuring the deformation response of the cells to controlled loading of fully intact cartilage using a custom-designed confocal indentation system. Early OA was achieved nine weeks following transection of the anterior cruciate ligament (ACL) in rabbit knees. Experiments were performed on the retropatellar cartilage of early OA rabbit knees (four joints and 48 cells), the corresponding intact contralateral control knees (four joints and 48 cells) and knees from normal control rabbits (four joints and 48 cells). Nine weeks following ACL transection, articular cartilage of the experimental joints showed substantial increases in thickness, and progression towards OA as assessed using his...Continue Reading

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Citations

Aug 31, 2011·Biomechanics and Modeling in Mechanobiology·Siru M TurunenRami K Korhonen
Apr 8, 2014·Connective Tissue Research·Mari R J HuttuRami K Korhonen
Jul 15, 2015·Journal of Biomechanics·J T A MäkeläR K Korhonen
Nov 26, 2015·Journal of Biomechanics·J M FickR K Korhonen
Aug 14, 2012·Journal of Biomechanics·Sang-Kuy HanWalter Herzog
Oct 24, 2012·Journal of Biomechanics·Ryan MaddenWalter Herzog
Mar 31, 2015·Clinics in Sports Medicine·Brian PietrosimoneJoe M Hart
May 24, 2014·Biomechanics and Modeling in Mechanobiology·Ryan M J MaddenWalter Herzog
Jul 9, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sang-Kuy HanRami K Korhonen
Apr 24, 2015·Exercise and Sport Sciences Reviews·Rami K KorhonenMika E Mononen
Aug 16, 2017·BMC Musculoskeletal Disorders·R RiegerT Hoc
May 20, 2020·Cellular and Molecular Bioengineering·Isaac O AfaraJuha Töyräs
Sep 23, 2020·Annals of Biomedical Engineering·Amin KomeiliWalter Herzog
Mar 20, 2019·Lipids in Health and Disease·Anne-Mari MustonenPetteri Nieminen

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