Mechanical, material, and biological study of a PCL/bioactive glass bone scaffold: Importance of viscoelasticity

Materials Science & Engineering. C, Materials for Biological Applications
Alireza Shahin-ShamsabadiFatemeh Mashhadi Abbas

Abstract

Microsphere sintering method was used to fabricate bone tissue engineering scaffolds made of polycaprolactone (PCL)/bioactive glass 58S5Z (58S modified with 5 wt% Zinc). First, the effect of PCL/58S5Z ratio on the mechanical properties (elastic modulus and yield strength) was investigated. It was found that samples with 5 wt% 58S5Z (named 5%BG) had the highest elastic modulus and yield strength among all samples, i.e., with 0, 5, 10, and 20 wt% bioactive glass. Then, considering the importance of viscoelastic properties of bone, the viscoelastic behavior of 0%BG (scaffold with only PCL) and 5%BG samples was determined by performing compressive stress relaxation test and subsequently a Generalized Maxwell model was developed. Findings indicated a similar amount and pattern of predicted storage and loss moduli and loss factor of the composite scaffolds to those of the bone. In the next step, the analysis of biological behavior of the scaffolds using MTT assay, DAPI and Alizarin red staining demonstrated that 5%BG scaffolds had higher in vitro cell viability and bone formation compared to 0%BG ones. Furthermore, in vivo study employing H&E staining of the scaffolds implanted in rats' calvarium for 50 days, confirmed the earlier fi...Continue Reading

Citations

Aug 21, 2019·Drug Delivery and Translational Research·Mir Hamed NabaviHossein Semyari
Aug 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zoi TerzopoulouDimitrios Bikiaris
May 1, 2020·Journal of Materials Science. Materials in Medicine·Gabriela Fernandes da FonsecaAlexandre Luiz Souto Borges
Jul 9, 2020·Soft Matter·A BonfantiA Kabla
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·R HanP J Walsh
Jun 18, 2021·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Majid SiamiMousa Rezaee
Feb 8, 2021··MK SathyadeepDayanand Pai

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