Dec 15, 1975

Mechanical precipitation of hemoglobin köln

Biochimica Et Biophysica Acta
T AsakuraE Schwartz

Abstract

Hb Köln (beta 98 Val leads to Met) was found to precipitate rapidly during mechanical shaking. The rate of precipitation of Hb Köln is 5-6 times faster than that of Hb S. The kinetics of precipitation of the patient's hemolysate, which is a mixture of Hb Köln and Hb A, showed a biphasic curve indicating that Hb Köln precipitates independently from Hb A. The instability of Hb Köln may be attributed to the conformational change in the vicinity of heme. The mechanical shaking may be used as a new method for detection and quantitation of hemoglobin Köln and other unstable hemoglobins.

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  • Citations2

References

  • References3
  • Citations2

Citations

Mentioned in this Paper

Valine
poly(N(alpha), N(epsilon) L-lysinediylterephthaloyl)hemolysate capsules
Hemoglobin SS
Hemoglobin Koln
Pedameth
Tremor
Hemoglobin Measurement
Abnormal Hemoglobins
Hemoglobin A
Hemoglobin

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