Mechanical properties and antibiotic release characteristics of poly(methyl methacrylate)-based bone cement formulated with mesoporous silica nanoparticles

Journal of the Mechanical Behavior of Biomedical Materials
Kumaran LetchmananReginald Beng Hee Tan

Abstract

The influence of mesoporous silica nanoparticles (MSNs) loaded with antibiotics on the mechanical properties of functional poly(methyl methacrylate)-(PMMA) based bone cements is investigated. The incorporation of MSNs to the bone cements (8.15wt%) shows no detrimental effects on the biomechanical properties of the freshly solidified bone cements. Importantly, there are no significant changes in the compression strength and bending modulus up to 6 months of aging in PBS buffer solution. The preserved mechanical properties of MSN-functionalized bone cements is attributed to the unchanged microstructures of the cements, as more than 96% of MSNs remains in the bone cement matrix to support the cement structures after 6 months of aging. In addition, the MSN-functionalized bone cements are able to increase the drug release of gentamicin (GTMC) significantly as compared with commercially available antibiotic-loaded bone cements. It can be attributed to the loaded nano-sized MSNs with uniform pore channels which build up an effective nano-network path enable the diffusion and extended release of GTMC. The combination of excellent mechanical properties and sustainable drug delivery efficiency demonstrates the potential applicability of ...Continue Reading

Citations

Oct 13, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Annett KlinderRainer Bader
Oct 5, 2018·Plastic and Reconstructive Surgery·Adriana C Panayi, Dennis P Orgill
Apr 28, 2019·International Journal of Molecular Sciences·Jiaying LiBin Li
Aug 8, 2020·Frontiers in Chemistry·Vanitha SelvarajanPui Lai Rachel Ee
Sep 23, 2020·Chinese Medical Journal·Yi-Ming XuXi-Sheng Weng
Dec 4, 2020·Biomolecules·Mayra Eliana Valencia ZapataJosé Herminsul Mina Hernandez
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Sunjung KimHeidi-Lynn Ploeg
May 16, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Li WanHongyu Zhang
Jan 18, 2018·Journal of the Mechanical Behavior of Biomedical Materials·Hamed Aghajani Derazkola, Abdolreza Simchi
Mar 25, 2021·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Bret WaligoraCarolyn Brookes
Apr 4, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Kutsi TuncerÖmer Gündoğdu
Apr 23, 2021·Macromolecular Bioscience·Chao-Yi LuHorst A von Recum
Jul 9, 2021·International Journal of Nanomedicine·Rafael R Castillo, María Vallet-Regí
Sep 23, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Prabaha SikderSarit B Bhaduri
Sep 30, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·K R Sneha, G S Sailaja

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

Materials Science & Engineering. C, Materials for Biological Applications
Shou-Cang ShenReginald Beng Hee Tan
Journal of Medical Engineering & Technology
A J LeeS S Vangala
© 2022 Meta ULC. All rights reserved