Mechanical properties of human tympanic membrane in the quasi-static regime from in situ point indentation measurements

Hearing Research
Jef AernoutsJoris J J Dirckx

Abstract

The tympanic membrane is a key component of the human auditory apparatus. Good estimates of tympanic membrane mechanical properties are important to obtain realistic models of middle ear mechanics. Current literature values are almost all derived from direct mechanical tests on cut-out strips. For a biomedical specimen like the tympanic membrane, it is not always possible to harvest strips of uniform and manageable geometry and well-defined size suitable for such mechanical tests. In this work, elastic and viscoelastic properties of human tympanic membrane were determined through indentation testing on the tympanic membrane in situ. Indentation experiments were performed on three specimens with a custom-built apparatus that was also used in previously published works. Two types of indentation tests were performed on each specimen: (i) sinusoidal indentation at 0.2 Hz yielding the quasi-static Young's modulus and (ii) step indentation tests yielding viscoelastic properties in the quasi-static regime (0-20 Hz). In the cyclic indentation experiments (type i), the indentation depth and resulting needle force were recorded. The unloaded shape of the tympanic membrane and the membrane thickness were measured and used to create a spec...Continue Reading

References

Jun 1, 1991·Archives of Otolaryngology--head & Neck Surgery·C B RuahT H Yoon
Jun 1, 1987·The Journal of the Acoustical Society of America·W R FunnellS M Khanna
Oct 1, 1972·The Journal of the Acoustical Society of America·J Tonndorf, S M Khanna
Sep 1, 1970·Acta Oto-laryngologica·D J Lim
Jan 1, 1982·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·W R Funnell, C A Laszlo
Jan 1, 1980·Journal of Biomechanics·W F DecraemerV J Vanhuyse
Mar 10, 2000·Journal of Biomechanics·P Ferris, P J Prendergast
Jul 27, 2001·Hearing Research·J J Dirckx, W F Decraemer
Nov 1, 1960·Journal of the Optical Society of America·G V BEKESY
Nov 5, 2003·Biomechanics and Modeling in Mechanobiology·Q SunK J Dormer
Dec 18, 2004·The Journal of the Acoustical Society of America·Hanif M LadakW Robert J Funnell
Jul 19, 2005·Journal of Biomechanics·Jonathan FayCharles Steele
May 26, 2006·Journal of the Association for Research in Otolaryngology : JARO·Yael MarcusohnAmos Ar
Oct 18, 2006·Journal of the Association for Research in Otolaryngology : JARO·Nidal ElkhouriW Robert J Funnell
Dec 13, 2006·Annals of Biomedical Engineering·Tao ChengRong Z Gan
Dec 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jonathan P FayCharles R Steele
May 22, 2007·Biomaterials·Wei ZhangGhassan S Kassab
Aug 4, 2007·The Journal of the Acoustical Society of America·Xuelin WangRong Z Gan
Jul 24, 2008·The Journal of the Acoustical Society of America·James P Tuck-LeeSunil Puria
May 20, 2009·Journal of Biomechanical Engineering·Huiyang LuoHongbing Lu
Jul 25, 2009·Journal of the Mechanical Behavior of Biomedical Materials·Nitin P DaphalapurkarHongbing Lu
Aug 1, 2009·Medical Engineering & Physics·Fei ZhaoRhys Meredith
Dec 26, 2009·Hearing Research·Jeffrey Tao ChengJohn J Rosowski
Apr 16, 2010·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Michael GaihedeKjell Tveterås
Nov 12, 2010·Biomechanics and Modeling in Mechanobiology·Jef Aernouts, Joris J J Dirckx
Mar 8, 2011·Journal of Biomechanics·G VolandriC Carmignani
Feb 14, 2012·Journal of Biomechanics·Jef Aernouts, Joris J J Dirckx

❮ Previous
Next ❯

Citations

May 16, 2013·Journal of the Association for Research in Otolaryngology : JARO·Sam Van der JeughtJan A N Buytaert
Jul 24, 2012·Annals of Biomedical Engineering·Xiangming Zhang, Rong Z Gan
Nov 8, 2013·Journal of the Royal Society, Interface·Robert MalkinDaniel Robert
Jan 3, 2016·Hearing Research·Pieter G G MuyshondtJoris J J Dirckx
Dec 25, 2015·Hearing Research·Daniel De GreefJoris J J Dirckx
Oct 9, 2016·Journal of the Association for Research in Otolaryngology : JARO·Hamid MotallebzadehSam J Daniel
Apr 5, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Cuneyt M AlperDennis S Poe
Jul 23, 2015·Journal of the Association for Research in Otolaryngology : JARO·Nima MaftoonWillem F Decraemer
Jun 6, 2019·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Pengpeng XieShengen Yi
Aug 13, 2020·Journal of the Association for Research in Otolaryngology : JARO·Junfeng LiangRong Z Gan
Dec 18, 2012·Biomedical Optics Express·Silvino M SolísFernando M Santoyo
Sep 27, 2018·Journal of Biomedical Optics·Payam RazaviJeffrey T Cheng
May 5, 2021·Advanced Healthcare Materials·Shivesh AnandCarlos Mota

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.