Mechanical properties of single hyaluronan molecules

Journal of Biomechanics
Tadashi FujiiZong-Ping Luo

Abstract

Hyaluronan (HA) is a major component of the extracellular matrix. It plays an important role in the mechanical functions of the extracellular matrix and stabilization of cells. Currently, its mechanical properties have been investigated only at the gross level. In this study, the mechanical properties of single HA molecules were directly measured with an optical tweezer technique, yielding a persistence length of 4.5 +/- 1.2 nm. This information may help us to understand the mechanical roles in the extracellular matrix infrastructure, cell attachment, and to design tissue engineering and drug delivery systems where the mechanical functions of HA are essential.

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Citations

Mar 17, 2004·Biochemical and Biophysical Research Communications·Xuhui LiuZong-Ping Luo
Jul 20, 2006·Journal of the Royal Society, Interface·S J EppellR Ballarini
Sep 4, 2013·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Charles J WhiteMark E Byrne
Nov 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·A EhrlicherJ Kas
Jul 14, 2012·Annual Review of Materials Research·Lin HanChristine Ortiz
Jul 19, 2005·Journal of Biomechanics·Joonil SeogChristine Ortiz
Dec 5, 2006·Biophysical Journal·Lin HanAlan J Grodzinsky
Nov 18, 2005·Journal of Biomechanics·Delphine DeanChristine Ortiz
Nov 3, 2005·Biochemical and Biophysical Research Communications·Xuhui LiuZong-Ping Luo
Apr 16, 2016·Soft Matter·Kenneth S Rankin, Daniel Frankel
Jul 2, 2010·Advanced Materials·Soheil Boddohi, Matt J Kipper
Apr 14, 2016·Macromolecular Bioscience·E Rodríguez-PérezC Martínez-Ramos
Apr 12, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Shambo Bhattacharya, Devendra K Dubey
Feb 10, 2009·Biomacromolecules·Thomas Crouzier, Catherine Picart

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