PMID: 684667Jun 1, 1978Paper

Mechanical properties of the lung in extrinsic allergic alveolitis

Thorax
C P WarrenR M Cherniack

Abstract

The lung function of 14 patients with extrinsic allergic alveolitis caused by exposure to mouldy hay (farmer's lung) or to birds (bird fancier's lung) was studied one week and four to six weeks after the last exposure to antigen. These data, together with lung mechanics measured four weeks after antigen exposure, were compared with measurements in 34 healthy non-smoking control subjects. Shortly after exposure to antigen there were reduction in lung volumes, increased elastic recoil (reduced compliance), and varied effects on expiratory flow and reduced gas transfer. With time, lung volumes and gas transfer improved, but expiratory flow often remained decreased. The data on lung mechanics showed that reduced compliance was often found, but this increased recoil did not always produce high airflow indicating increased upstream airways resistance. Patients with a longer duration of the illness tended to have increased compliance (reduced recoil) and low airflow. These results show that the described pathological changes of airway involvement, fibrosis, and emphysema in allergic alveolitis are manifest in the lung function of patients with the disease.

References

Oct 1, 1977·The American Review of Respiratory Disease·G J Gibson, N B Pride
Feb 1, 1976·Chest·G J Gibson, N B Pride
Jul 1, 1972·The American Review of Respiratory Disease·R M Cherniack, M B Raber
Mar 1, 1969·Annals of Internal Medicine·D P SchlueterA J Sosman
Jan 1, 1967·Journal of Applied Physiology·J MeadJ B Little
Aug 29, 1955·The Journal of Physiology·D V BATESA E DORMER
Mar 1, 1964·Journal of Applied Physiology·J MILIC-EMILIE M GLAUSER

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Citations

Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine
Apr 1, 1993·The American Review of Respiratory Disease·J I KokkarinenE O Terho
Aug 25, 2005·Paediatric Drugs·Purnima Venkatesh, Laurianne Wild
Jan 1, 1990·Respiratory Medicine·G Boyd
Mar 1, 1989·Respiratory Medicine·J de GraciaR Orriols
Oct 4, 2000·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·D M Hansell
Feb 18, 1998·Radiologic Clinics of North America·H Arakawa, W R Webb
Mar 5, 2003·Clinics in Sports Medicine·Jonathon Truwit
Nov 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S J BourkeG Boyd
Aug 1, 1978·Thorax·D J HendrickR Marshall
Aug 15, 2018·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Alireza Karimi, Reza Razaghi
Jul 1, 1991·Disease-a-month : DM·O P Sharma

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