Mechanical property anisotropy of pharmaceutical excipient compacts

International Journal of Pharmaceutics
Matthew P Mullarney, Bruno C Hancock

Abstract

The mechanical property anisotropy of compacts made from six commercially available pharmaceutical excipient powders was evaluated. Uni-axially compressed cubic compacts of each excipient were subjected to pendulum impact testing and transverse tensile testing in several orientations. The pendulum impact test was used to measure the dynamic indentation hardness of each compact face (side, top, and bottom). Transverse tensile testing was utilized to determine the compact axial and radial tensile strength values. The indentation hardness (top>bottom>side) and tensile strength tests (radial>axial) revealed mechanical property anisotropy in all the compacts. The extent of mechanical property anisotropy was quantified by using dimensionless ratios and was found to be significantly different for each material. In general, compacts with a higher degree of compact mechanical anisotropy also exhibited a higher brittle fracture index (BFI). This suggests that the macroscopic flaws intentionally made in the compact for the BFI measurement were similar to the flaws induced in highly anisotropic materials during uni-axial compaction. These results are consistent with the practical observation that brittle materials are more likely to exhibi...Continue Reading

References

Jul 1, 1986·The Journal of Pharmacy and Pharmacology·R J Roberts, R C Rowe
Nov 6, 2001·Drug Development and Industrial Pharmacy·S EdgeA Chen
Apr 25, 2003·International Journal of Pharmaceutics·Matthew P MullarneyBeth A Langdon

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Citations

Apr 24, 2008·AAPS PharmSciTech·Yu San WuKees van der Voort Maarschalk
May 9, 2014·International Journal of Pharmaceutics·Vincent MazelPierre Tchoreloff
May 12, 2009·International Journal of Pharmaceutics·I AkseliC Cetinkaya
Jul 16, 2008·International Journal of Pharmaceutics·Victoria M Masterson, Xiaoping Cao
Mar 11, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ai Ling ChingPaul Wan Sia Heng
Jul 19, 2015·International Journal of Pharmaceutics·Ryoichi FurukawaShinji Narisawa
Jun 9, 2011·Pharmaceutical Development and Technology·Christine CahyadiPaul Wan Sia Heng
Jul 11, 2012·International Journal of Pharmaceutics·Fridrun Podczeck
Apr 7, 2010·International Journal of Pharmaceutics·Jingfei Liu, Cetin Cetinkaya
Dec 8, 2011·Current Protocols in Pharmacology·Padma Narayan
Oct 17, 2018·Pharmaceutics·Ramon CabiscolArno Kwade
Jun 12, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Erik Alerstam, Tomas Svensson
Dec 18, 2019·International Journal of Pharmaceutics·Cheol-Hee ChoEun-Seok Park

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