Mechanical reinforcement of gellan gum polyelectrolyte hydrogels by cationic polyurethane soft nanoparticles

Carbohydrate Polymers
Maryam SahraroHamed Daemi

Abstract

Novel mechanically reinforced nanocomposite hydrogels (NCHs) were developed based on methacrylated gellan gum (MGG) and cationic polyurethane nanoparticles (CPUNs) through a green chemical approach. A series of NCHs were synthesized by the incorporation of CPUNs with weight ratios of 0, 10, 30 and 50 w/w% into the MGG solution, with two different methacrylation degrees (1.2, 5.6%). The chemical structure, morphology, mechanical properties, stimuli-responsivity and cytotoxicity of synthesized NCHs were investigated. Analysis of the hydrogels mechanical testing demonstrated that the addition of CPUNs affords the significant increase in compressive properties. Meanwhile, the formulation of NCH containing the MGG with lower methacrylation degree and 30 w/w% CPUNs showed the highest mechanical properties. Furthermore, equilibrium swelling ratio of the hydrogels decreased by CPUNs addition. Finally, it is worth mentioning that NCHs showed no significant toxicity to human dermal fibroblast cells (HDFs) which idealize them as the suitable hydrogels for biomedical applications.

Citations

Apr 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cornelia VasileMihaela Baican
Sep 26, 2020·Frontiers in Bioengineering and Biotechnology·Céline MullerJulien Barthes

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