Mechanical reliability of the Jarvik 2000 Heart

The Annals of Thoracic Surgery
Michael P SiegenthalerStephen Westaby

Abstract

Device failure is a limitation of permanent mechanical circulatory support. We studied the mechanical reliability of the Jarvik 2000 Heart, an axial flow pump with ceramic bearings designed to provide more than 10 years' durability. The Jarvik 2000 Heart was implanted in 102 patients between April 2000 and December 2004. Eighty-three pumps with an abdominal driveline were implanted as a bridge-to-transplantation, and 19 with postauricular power supply as lifetime therapy. Eighteen pumps were recovered intact after clinical use and run continuously on the bench to further assess durability. No implantable component failure occurred either in patients or during bench testing. The cumulative pump run-time was 110 years: 59 years overall in vivo and 51 years in vitro. The mean support time for bridge-to-transplant recipients was 159 days, and for discharged lifetime-therapy recipients 551 days. Six recipients were supported moer than 2 years, with the longest ongoing approaching 5 years. External cables caused three system failures, with a 95% freedom from system failure at 4 years. Device malfunctions, related to external cables (9) and lack of a backup battery (1), caused no adverse consequences. Before introduction of noncorrosi...Continue Reading

References

Jun 28, 2001·The Annals of Thoracic Surgery·G L GrunkemeierA Starr
Aug 22, 2001·Circulation·X Y JinA Banning
Sep 22, 2001·The Annals of Thoracic Surgery·G L Grunkemeier, Y Wu
Jan 17, 2002·The New England Journal of Medicine·E A RoseUNKNOWN Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group
Nov 25, 2004·The Annals of Thoracic Surgery·Walter P DembitskyJames W Long

❮ Previous
Next ❯

Citations

Jun 19, 2008·Nature Clinical Practice. Cardiovascular Medicine·Stephen Westaby
Jul 1, 2010·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Duc Q Nguyen, Vinod H Thourani
Oct 8, 2009·Biomedizinische Technik. Biomedical Engineering·Jan SpillnerRüdiger Autschbach
Aug 9, 2011·Cardiology Research and Practice·Jens GarbadeFriedrich-Wilhelm Mohr
Jul 23, 2014·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Daisuke YoshiokaYoshiki Sawa
Sep 2, 2014·International Journal of Cardiology·Gwendolyn DerkJamil Aboulhosn
Dec 25, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Nader MoazamiRandall C Starling
Jul 14, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Thomas Brent GallenAnand R Mehta
Jun 15, 2011·Medical Engineering & Physics·Daniel Timms
Oct 1, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Javier G CastilloGregory W Fischer
Nov 29, 2008·Seminars in Thoracic and Cardiovascular Surgery·Francis D Pagani
Nov 29, 2008·Seminars in Thoracic and Cardiovascular Surgery·Ranjit John
Jun 28, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Pippa M SchneeRoger J Bick
Nov 21, 2007·The Journal of Thoracic and Cardiovascular Surgery·Michael MarklFriedhelm Beyersdorf
Dec 8, 2007·Cardiology Clinics·O H Frazier, Leon P Jacob
Aug 29, 2007·Heart Failure Clinics·Manuel Prinz von BayernMario C Deng
Aug 29, 2007·Heart Failure Clinics·Stephen Westaby
Apr 26, 2008·Journal of Cardiac Surgery·Evgenij V PotapovRoland Hetzer
Apr 14, 2007·Pediatric Transplantation·Evgenij V PotapovRoland Hetzer
Mar 6, 2010·Journal of Cardiac Surgery·Sanjeev Aggarwal, Francis D Pagani
May 23, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hassan A KhalilKamuran A Kadipasaoglu
Sep 26, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Christoph BenkChristian Schlensak
Nov 13, 2009·Current Opinion in Anaesthesiology·Nanhi Mitter, Rosanne Sheinberg
May 13, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Carlos ReyesDaniel Tamez
Feb 13, 2016·The International Journal of Artificial Organs·Michele GalloTomaso Bottio
Sep 14, 2019·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Keitaro DomaeYoshiki Sawa
Mar 7, 2007·Expert Review of Cardiovascular Therapy·Tomasz Timek, Kai Ihnken
Mar 4, 2019·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Shunsuke SaitoYoshiki Sawa
Sep 22, 2009·Expert Review of Cardiovascular Therapy·Ana C Alba, Diego H Delgado
Sep 5, 2021·Surgery Today·Ikuko ShibasakiHirotsugu Fukuda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.