PMID: 8602661Feb 1, 1996Paper

Mechanical significance of respiratory muscle activity in humans during halothane anesthesia

Anesthesiology
D O WarnerE L Ritman

Abstract

Prior human studies have shown that halothane attenuates activity in the parasternal intercostal muscle and enhances phasic activity in respiratory muscles with expiratory actions. This expiratory muscle activity could contribute to reductions in the functional residual capacity produced by anesthesia. Termination of this activity could contribute to the maintenance of inspiratory rib cage expansion. The purpose of this study was to estimate in humans the mechanical significance of expiratory muscle activity during halothane anesthesia and to search for the presence of scalene muscle activity during halothane anesthesia that might contribute to inspiratory rib cage expansion. Six subjects (3 males, 3 females) were studied while awake and during 1.2 MAC halothane anesthesia, both during quiet breathing and during carbon dioxide rebreathing. Respiratory muscle activity was measured using fine-wire electromyography electrodes. Chest wall configuration was determined using images of the thorax obtained by three-dimensional, fast computed tomography and respiratory impedance plethysmography. Functional residual capacity was measured by a nitrogen dilution technique. Measurements were obtained after paralysis with 0.1 mg/kg vecuroniu...Continue Reading

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Citations

Jun 1, 1996·Trends in Neurosciences·A N AkopianJ N Wood
Feb 22, 2005·Journal of Clinical Anesthesia·Robert A SmithRafael V Miguel
Oct 17, 1998·Respiration Physiology·S IscoeJ Duffin
Oct 17, 1998·Progress in Neurobiology·S Iscoe
Jul 18, 2009·Journal of Applied Physiology·Alexandre LegrandPierre Alain Gevenois
May 19, 1998·Anesthesia and Analgesia·D O WarnerE L Ritman
Sep 2, 2011·Acta chirurgica Iugoslavica·Ana MandraNevena Kalezić
Nov 25, 2011·Current Opinion in Anaesthesiology·Gerardo TusmanJuraj Sprung
Jul 1, 1996·Anesthesiology·D O WarnerE L Ritman
Oct 1, 1996·Anesthesiology·D O WarnerE L Ritman
May 13, 1999·Anesthesiology·E SartonA Dahan
Sep 5, 2012·Respiratory Physiology & Neurobiology·Gordon B DrummondPhilippe Duvaldestin
May 17, 2019·Journal of Applied Physiology·Anthony F DiMarco, Krzysztof E Kowalski

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