Mechanical stability of the cell nucleus - roles played by the cytoskeleton in nuclear deformation and strain recovery

Journal of Cell Science
Xian WangYu Sun

Abstract

Extracellular forces transmitted through the cytoskeleton can deform the cell nucleus. Large nuclear deformations increase the risk of disrupting the integrity of the nuclear envelope and causing DNA damage. The mechanical stability of the nucleus defines its capability to maintain nuclear shape by minimizing nuclear deformation and allowing strain to be minimized when deformed. Understanding the deformation and recovery behavior of the nucleus requires characterization of nuclear viscoelastic properties. Here, we quantified the decoupled viscoelastic parameters of the cell membrane, cytoskeleton, and the nucleus. The results indicate that the cytoskeleton enhances nuclear mechanical stability by lowering the effective deformability of the nucleus while maintaining nuclear sensitivity to mechanical stimuli. Additionally, the cytoskeleton decreases the strain energy release rate of the nucleus and might thus prevent shape change-induced structural damage to chromatin.

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Citations

Feb 21, 2019·Nucleus·Marcel DregerJavier Redondo-Muñoz
Feb 23, 2020·Biorheology·Daniele BorinOrfeo Sbaizero
Mar 14, 2019·Cells·Jungwon Hah, Dong-Hwee Kim
Sep 15, 2020·Science Advances·Yonit TsatskisHelen McNeill
Sep 19, 2020·Journal of Nanobiotechnology·Yuri M EfremovPeter S Timashev
Jun 18, 2020·Frontiers in Cell and Developmental Biology·Tony FischerClaudia Tanja Mierke
Apr 14, 2020·International Journal of Nanomedicine·Alexander J SteevesFabio Variola
May 28, 2020·Cells·Francesca DonnalojaManuela Teresa Raimondi
Apr 23, 2020·Scientific Reports·Diego Herráez-AguilarJavier Redondo-Muñoz
Jul 10, 2020·Cells·Chad M Hobson, Andrew D Stephens
Dec 18, 2020·Nucleic Acids Research·Ália Dos SantosChristopher P Toseland

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