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Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines

Cancer Research

Jun 7, 2011

Vinay SwaminathanRichard Superfine

Abstract

Cancer cells are defined by their ability to invade through the basement membrane, a critical step during metastasis. While increased secretion of proteases, which facilitates degradation of the basement membrane, and alterations in the cytoskeletal architecture of cancer cells have bee...read more

Mentioned in this Paper

TGF beta type III receptor
Tumor Cells, Uncertain Whether Benign or Malignant
Biochemical Pathway
Matrigel
Cell Motility
Peptide Hydrolases
Ovarian Neoplasm
Muscular Stiffness
Neoplasms
Biomechanical Compliance
1
467
Paper Details
References
  • References18
  • Citations165
12
  • References18
  • Citations165
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Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines

Cancer Research

Jun 7, 2011

Vinay SwaminathanRichard Superfine

PMID: 21642375

DOI: 10.1158/0008-5472.can-11-0247

Abstract

Cancer cells are defined by their ability to invade through the basement membrane, a critical step during metastasis. While increased secretion of proteases, which facilitates degradation of the basement membrane, and alterations in the cytoskeletal architecture of cancer cells have bee...read more

Mentioned in this Paper

TGF beta type III receptor
Tumor Cells, Uncertain Whether Benign or Malignant
Biochemical Pathway
Matrigel
Cell Motility
Peptide Hydrolases
Ovarian Neoplasm
Muscular Stiffness
Neoplasms
Biomechanical Compliance
1
467

Similar Papers Found In These Feeds

Precision Medicine

Precision medicine is a medical model that proposes the customization of healthcare, with medical decisions, treatments, practices, or products being tailored to the patient traits and specific molecular features of disease processes. In this model, diagnostic testing is often employed for selecting appropriate and optimal therapies based on the context of a patient’s genetic content or other molecular or cellular analysis. Tools employed in precision medicine can include molecular diagnostics, imaging, and analytics

Cytoskeletal Collection

The cytoskeleton is a dynamic network of interlinking protein filaments that extends from the plasma membrane to the nucleus. Here is the latest research.

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Nature Nanotechnology

Nanomechanical analysis of cells from cancer patients

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Paper Details
References
  • References18
  • Citations165
12
  • References18
  • Citations165
12345...
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