Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways.

American Journal of Physiology. Lung Cellular and Molecular Physiology
Raja-Elie E AbdulnourPaul M Hassoun

Abstract

Xanthine oxidoreductase (XOR) plays a prominent role in acute lung injury because of its ability to generate reactive oxygen species. We investigated the role of XOR in ventilator-induced lung injury (VILI). Male C57BL/6J mice were assigned to spontaneous ventilation (sham) or mechanical ventilation (MV) with low (7 ml/kg) and high tidal volume (20 ml/kg) for 2 h after which lung XOR activity and expression were measured and the effect of the specific XOR inhibitor allopurinol on pulmonary vascular leakage was examined. In separate experiments, rat pulmonary microvascular endothelial cells (RPMECs) were exposed to cyclic stretch (5% and 18% elongation, 20 cycles/min) for 2 h before intracellular XOR activity measurement. Lung XOR activity was significantly increased at 2 h of MV without changes in XOR expression. There was evidence of p38 MAP kinase, ERK1/2, and ERK5 phosphorylation, but no change in JNK phosphorylation. Evans blue dye extravasation and bronchoalveolar lavage protein concentration were significantly increased in response to MV, changes that were significantly attenuated by pretreatment with allopurinol. Cyclic stretch of RPMECs also caused MAP kinase phosphorylation and a 1.7-fold increase in XOR activity, whic...Continue Reading

References

Mar 1, 1992·Journal of Applied Physiology·C E PattersonJ G Garcia
Aug 1, 1990·The American Review of Respiratory Disease·T C CorbridgeJ I Sznajder
Jun 1, 1989·The American Review of Respiratory Disease·J G GarciaK S Callahan
Jan 1, 1989·Free Radical Biology & Medicine·J S BeckmanB A Freeman
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Dec 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J C ParkerJ Thigpen
Oct 1, 1996·Critical Care Medicine·H F GalleyN R Webster
Nov 1, 1996·The American Journal of Physiology·C G CoteP M Hassoun
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·G J QuinlanJ M Gutteridge
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·D Dreyfuss, G Saumon
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·A S Slutsky, L N Tremblay
Jul 9, 1998·American Journal of Respiratory and Critical Care Medicine·P M HassounJ J Lanzillo
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Oct 6, 2000·Clinics in Chest Medicine·K P Steinberg, L D Hudson
Oct 29, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·M A MoxleyJ A Corbett
Mar 30, 2001·The Journal of Biological Chemistry·U S KayyaliP M Hassoun
Sep 5, 2002·Free Radical Biology & Medicine·Roger Harrison
Nov 5, 2002·The European Respiratory Journal·U UhligS Uhlig
Mar 18, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Konstantin G BirukovJoe G N Garcia
Jun 10, 2003·Critical Care : the Official Journal of the Critical Care Forum·James A Frank, Michael A Matthay
Sep 12, 2003·Trends in Immunology·Claudia VorbachMario R Capecchi
Dec 3, 2003·American Journal of Respiratory and Critical Care Medicine·Li-Fu LiDeborah A Quinn
Mar 17, 2004·American Journal of Respiratory and Critical Care Medicine·Xinqi PengJoe G N Garcia
Nov 2, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Masaaki Hayashi, Jiing-Dwan Lee
Jun 7, 2005·American Journal of Respiratory and Critical Care Medicine·Xinqi PengPaul M Hassoun
Oct 1, 1965·The Biochemical Journal·U A Al-Khalidi, T H Chaglassian

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Citations

Sep 8, 2007·Antioxidants & Redox Signaling·Sekhar P ReddyRoy Brower
Feb 4, 2009·Antioxidants & Redox Signaling·Konstantin G Birukov
Jul 19, 2011·Critical Care Medicine·Panfeng FuKonstantin G Birukov
Jul 8, 2011·Journal of the Royal Society, Interface·Deshun Lu, Ghassan S Kassab
May 20, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Emilie C VielErnesto L Schiffrin
May 11, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Katerina VaporidiWarren M Zapol
Oct 14, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Eric P SchmidtDavid B Pearse
Apr 14, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·James H FiniganPaul M Hassoun
Sep 29, 2007·American Journal of Respiratory and Critical Care Medicine·Srinivas PapaiahgariSekhar P Reddy
May 15, 2012·American Journal of Respiratory and Critical Care Medicine·Moo Suk ParkIvor S Douglas
Apr 21, 2010·Critical Care : the Official Journal of the Critical Care Forum·Nikolaos A ManiatisAnastasia Kotanidou
Mar 7, 2014·Cell and Tissue Research·Holger C Müller-RedetzkyMartin Witzenrath
May 28, 2011·Intensive Care Medicine·Chi-Huei ChiangHaibo Zhang
Jan 22, 2008·Langenbeck's Archives of Surgery·Parimal Chowdhury, Azida Walker
Jul 29, 2011·The American Journal of the Medical Sciences·James D GladdenLouis J Dell'Italia
Sep 20, 2011·Free Radical Biology & Medicine·James D GladdenLouis J Dell'Italia
Dec 2, 2008·Microvascular Research·Adel Boueiz, Paul M Hassoun
Dec 4, 2012·European Journal of Pharmacology·Pedro GonçalvesFátima Martel
Dec 2, 2015·Physiological Reports·R Scott StephensMahendra Damarla
Oct 16, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Wan-Chao YangHua-Cheng Zhou
Jul 4, 2018·The Journal of Physiology·Patricia MarchioMaria D Mauricio
Jan 16, 2008·Current Opinion in Critical Care·Nikolaos A Maniatis, Stylianos E Orfanos
Jun 8, 2010·Anesthesiology·David J KrodelMatthias Eikermann
Nov 9, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dolly MehtaWolfgang M Kuebler
Dec 17, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ting WangStephen M Black
Aug 26, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mehdi A FiniEllen L Burnham
Mar 15, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Samantha J WoodsMichael R Wilson
Apr 8, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Grzegorz GawlakKonstantin G Birukov
Oct 19, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Feng WuBryan J McVerry
Sep 14, 2019·Tobacco Induced Diseases·Parimal ChowdhuryEmber R Fenton

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