Mechanical stretch induces nerve sprouting in rat sympathetic neurocytes

Autonomic Neuroscience : Basic & Clinical
Obaida R RanaErol Saygili

Abstract

Sympathetic nerve sprouting (SNS) has been shown to occur after myocardial infarction (MI) and heart failure (HF) and is known to be responsible for the development of lethal arrhythmias. During MI or HF intracardiac cells are exposed to increased mechanical stretch. Molecular mechanisms which trigger sympathetic neural growth are largely unknown. Therefore, this study aimed to investigate the impact of mechanical stretch on rat neonatal sympathetic neurocytes of the superior cervical ganglion (SCG). Mechanical stretch resulted in an increased growth of sympathetic neurocytes. Furthermore, we could demonstrate that SCG neurocytes express nerve growth factor (NGF), ciliary neurotrophic factor (CNTF), neurotrophin-3 (NT-3) and glial derived neurotrophic factor (GDNF) on mRNA and protein level. An increased NGF and CNTF expression, a down-regulated GDNF expression and an unchanged NT-3 expression were identified in the neurocyte cell culture supernatant of neurocytes exposed to mechanical stretch. However, neither brain derived neurotrophic factor (BDNF) mRNA and protein was expressed in SCG neurocytes, nor BDNF could be detected in the cell culture supernatant of SCG neurons. By anti-neurotrophin neutralizing experiments NGF and ...Continue Reading

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Citations

Aug 5, 2010·Cellular and Molecular Neurobiology·Erol SaygiliObaida R Rana
Jan 19, 2016·Molecular and Cellular Endocrinology·Yanchun Liang, Shuzhong Yao
Jun 1, 2010·Autonomic Neuroscience : Basic & Clinical·Obaida R RanaErol Saygili
Nov 1, 2011·Journal of Cardiovascular Electrophysiology·Ayaka NumataHrayr S Karagueuzian
Apr 27, 2011·Neurourology and Urodynamics·Peter OchodnickýMartin C Michel
Jun 7, 2011·Biochemical and Biophysical Research Communications·Erol SaygiliObaida R Rana
Sep 8, 2017·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Wenfeng ShangguanXuewen Wang
Apr 19, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ryan E TomlinsonThomas L Clemens

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