Mechanical support and medical therapy reverse heart failure in infants and children

Artificial Organs
Hannah ZimmermanJack Copeland

Abstract

Most infants and children implanted with ventricular assist devices (VADs) go on to cardiac transplantation. Recovery of dilated cardiomyopathies with the combination left ventricular decompression with a VAD and treatment with maximal medical therapy has been possible in some adults, and may be more feasible in infants and children. We used pulsatile and continuous flow VADs and the total artificial heart (TAH) as bridges to transplantation or to recovery. Candidates for native heart recovery were treated with maximal medical therapy for congestive heart failure and short-term dobutamine prior to weaning off device support. Since 1997, 28 infants and children, ages 1 month to 16 years, were implanted for durations of 3-107 days (mean 27). Eighteen received left VADs (LVAD), seven biventricular assist devices (BiVADs), and three TAHs. Device-related mortality was 7/28 (25%), leaving 21/28 (75%) surviving to transplantation or weaning from device support and 20/28 (71%) discharged from the hospital and currently surviving for 2 months to 9 years. Ten of 11 transplant recipients (90%) have survived 2 to 9 years. All 10 with recovered hearts are alive and well for 2 months to 5 years. Eight of 12 (67%) LVAD patients with dilated h...Continue Reading

References

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Apr 30, 2008·The Annals of Thoracic Surgery·Jack G CopelandMarvin J Slepian

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Citations

May 21, 2011·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Takafumi InoueMinoru Ono
Mar 16, 2011·Artificial Organs·Paul S Malchesky
Nov 22, 2011·Artificial Organs·Hannah CopelandJack G Copeland
Apr 11, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Leonard L Bailey
Dec 25, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Xufeng WeiBartley P Griffith
Dec 22, 2010·The Annals of Thoracic Surgery·Jack Copeland, Hannah Zimmerman
Mar 11, 2015·The Annals of Thoracic Surgery·Parthak ProdhanUmesh Dyamenahalli
Jan 1, 2012·World Journal for Pediatric & Congenital Heart Surgery·Eugen SandicaMichiel Morshuis
Dec 3, 2016·The Journal of Pediatrics·Elizabeth MedinaBrian L Stauffer

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