Mechanical Ventilation Antioxidant Trial

American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses
Kimberly P HoweHugh Owen

Abstract

Many patients each year require prolonged mechanical ventilation. Inflammatory processes may prevent successful weaning, and evidence indicates that mechanical ventilation induces oxidative stress in the diaphragm, resulting in atrophy and contractile dysfunction of diaphragmatic myofibers. Antioxidant supplementation might mitigate the harmful effects of the oxidative stress induced by mechanical ventilation. To test the clinical effectiveness of antioxidant supplementation in reducing the duration of mechanical ventilation. A randomized, prospective, placebo-controlled double-blind design was used to test whether enterally administered antioxidant supplementation would decrease the duration of mechanical ventilation, all-cause mortality, and length of stay in the intensive care unit and hospital. Patients received vitamin C 1000 mg plus vitamin E 1000 IU, vitamin C 1000 mg plus vitamin E 1000 IU plus N-acetylcysteine 400 mg, or placebo solution as a bolus injection via their enteral feeding tube every 8 hours. Clinical and statistically significant differences in duration of mechanical ventilation were seen among the 3 groups (Mantel-Cox log rank statistic = 5.69, df = 1, P = .017). The 3 groups did not differ significantly i...Continue Reading

References

Jan 1, 1989·Intensive Care Medicine·Y BertrandC Deby
May 1, 1996·The American Journal of Clinical Nutrition·C J SchorahA Bodenham
Apr 8, 1999·Intensive Care Medicine·P G MetnitzW Druml
Jul 13, 2000·Critical Care Medicine·J M Alonso de VegaL F Carbonell
Aug 7, 2002·Critical Care Medicine·José M Alonso de VegaLuis F Carbonell
Jun 5, 2003·Journal of Applied Physiology·Murat A ZergerogluScott K Powers
Nov 13, 2004·Annals of Internal Medicine·Edgar R MillerEliseo Guallar
May 6, 2006·Journal of Applied Physiology·D J FalkS K Powers
Mar 28, 2008·The New England Journal of Medicine·Sanford LevineJoseph B Shrager
Feb 3, 2009·Free Radical Biology & Medicine·Andreas N KavazisScott K Powers
Mar 6, 2010·Journal of Applied Physiology·Melissa A WhiddenScott K Powers
May 8, 2010·American Journal of Respiratory and Critical Care Medicine·Judith E NelsonShannon S Carson
Jan 21, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Leslie Reddell, Bryan A Cotton
Apr 27, 2012·Critical Care : the Official Journal of the Critical Care Forum·William ManzanaresDaren K Heyland

❮ Previous
Next ❯

Citations

Jul 2, 2016·Current Infectious Disease Reports·Yin Li, Guoping Li
Jun 18, 2016·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·W A C Kristine Koekkoek, Arthur R H van Zanten
May 17, 2018·American Journal of Respiratory Cell and Molecular Biology·Huibin Tang, Joseph B Shrager
Nov 9, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tetsuya TamuraBrian P Kavanagh
Oct 27, 2018·SAGE Open Medicine·Michael Zhang, David F Jativa
Dec 13, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Jake T B CollieRinaldo Bellomo
Aug 14, 2019·Anesthesiology·Nikolay MorozSabah N Hussain
Jul 10, 2020·Experimental Biology and Medicine·Andréa Cristiane Lopes da SilvaFrank Silva Bezerra
Apr 3, 2019·Nutrients·Harri Hemilä, Elizabeth Chalker
Nov 21, 2020·Medicina·Alfredo Aisa-AlvarezIsrael Pérez-Torres
Jan 8, 2021·Critical Care : the Official Journal of the Critical Care Forum·Sean S ScholzSebastian Rehberg
Jul 30, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Kiran Kumar GudivadaBhuvana Krishna
May 7, 2020·Redox Biology·M C Gomez-CabreraJ Viña
Mar 9, 2021·Computational and Structural Biotechnology Journal·Adrián Palacios ChavarríaMaria Elena Soto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.