Mechanical ventilation during extracorporeal life support (ECLS): a systematic review

Intensive Care Medicine
Jonathan D MarhongEddy Fan

Abstract

In patients with acute respiratory distress syndrome (ARDS), extracorporeal life support (ECLS) has been utilized to support gas exchange and mitigate ventilator-induced lung injury (VILI). The optimal ventilation settings while on ECLS are unknown. The purpose of this systematic review is to describe the ventilation practices in patients with ARDS who require ECLS. We electronically searched MEDLINE, EMBASE, CENTRAL, AMED, and HAPI (inception to January 2015). Studies included were randomized controlled trials, observational studies, or case series (≥4 patients) of ARDS patients undergoing ECLS. Our review focused on studies describing ventilation practices employed during ECLS for ARDS. Forty-nine studies (2,042 patients) met our inclusion criteria. Prior to initiation of ECLS, at least one parameter consistent with injurious ventilation [tidal volume >8 mL/kg predicted body weight (PBW), peak pressure >35 cmH2O (or plateau pressure >30 cmH2O), or FiO2 ≥0.8] was noted in 90% of studies. After initiation of ECLS, studies reported median [interquartile range (IQR)] reductions in: tidal volume [2.4 mL/kg PBW (2.2-2.9)], plateau pressure [4.3 cmH2O (3.5-5.8)], positive end-expiratory pressure (PEEP) [0.20 cmH2O (0-3.0)], and FiO2...Continue Reading

References

Oct 20, 1977·The New England Journal of Medicine·N M AurigemmaE G Lowrie
Jan 1, 1992·Intensive Care Medicine·B Lachmann
Aug 15, 1986·JAMA : the Journal of the American Medical Association·L GattinoniA Agostoni
Jun 1, 1994·American Journal of Respiratory and Critical Care Medicine·F BrunetJ Dall'ava-Santucci
Sep 1, 1996·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·M MachaS M Pham
Mar 1, 1997·British Journal of Anaesthesia·R RossaintK Falke
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Oct 25, 2000·American Journal of Surgery·G MolsA Benzing
Sep 15, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·T C Carpenter, K R Stenmark
Jan 16, 2002·American Journal of Respiratory and Critical Care Medicine·James A FrankMichael A Matthay
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·C MadjdpourB Beck-Schimmer
May 29, 2003·American Journal of Respiratory and Critical Care Medicine·Antoine Vieillard-Baron, Francois Jardin
Aug 6, 2005·American Journal of Respiratory and Critical Care Medicine·David N HagerUNKNOWN ARDS Clinical Trials Network
Oct 19, 2005·Intensive Care Medicine·Lorraine N Tremblay, Arthur S Slutsky
Oct 21, 2005·The New England Journal of Medicine·Gordon D RubenfeldLeonard D Hudson
Dec 15, 2005·JAMA : the Journal of the American Medical Association·Eddy FanThomas E Stewart
Mar 17, 2006·Critical Care Medicine·Thomas BeinHans J Schlitt
Oct 14, 2006·American Journal of Respiratory and Critical Care Medicine·Pier Paolo TerragniV Marco Ranieri
Dec 25, 2007·The Annals of Thoracic Surgery·Manuela IglesiasPaolo Macchiarini
Feb 3, 2009·Critical Care : the Official Journal of the Critical Care Forum·Markus ZimmermannHans J Schlitt
Nov 4, 2009·Critical Care Medicine·Marjolein de WitScott K Epstein
Dec 19, 2009·Critical Care : the Official Journal of the Critical Care Forum·Thomas MüllerMatthias Lubnow
Jan 19, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Darren H FreedUNKNOWN Canadian Critical Care Trials Group
Mar 15, 2011·The Journal of Thoracic and Cardiovascular Surgery·Massimo BonacchiGuido Sani
Apr 8, 2011·The New England Journal of Medicine·Margaret S HerridgeUNKNOWN Canadian Critical Care Trials Group
Oct 7, 2011·JAMA : the Journal of the American Medical Association·Moronke A NoahKathryn M Rowan
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Jan 10, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Sylvain BeurtheretPascal Leprince

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Citations

Dec 10, 2015·Current Opinion in Critical Care·Darryl Abrams, Daniel Brodie
Oct 21, 2016·Intensive Care Medicine·Laurent PapazianAlain Combes
Nov 30, 2016·Current Opinion in Critical Care·Luciano GattinoniMichael Quintel
Nov 23, 2016·Current Opinion in Critical Care·Domenico L GriecoLaurent Brochard
Oct 17, 2017·Critical Care Medicine·Darryl Abrams, Daniel Brodie
Nov 16, 2017·Current Opinion in Critical Care·Darryl AbramsDaniel Brodie
Oct 4, 2018·American Journal of Respiratory and Critical Care Medicine·Eddy Fan
Jan 26, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Lieuwe D BosMarcus J Schultz
Jan 26, 2017·Biomedizinische Technik. Biomedical Engineering·Christian BrendleMarian Walter
Nov 15, 2019·American Journal of Respiratory and Critical Care Medicine·Darryl AbramsDaniel Brodie
Feb 25, 2020·Expert Review of Respiratory Medicine·Soo Jin Na, Kyeongman Jeon
Dec 18, 2018·Critical Care Medicine·Eddy Fan
Sep 14, 2017·Critical Care : the Official Journal of the Critical Care Forum·Davide ChiumelloJean-Louis Vincent
May 5, 2017·Intensive Care Medicine·Alain CombesLaurent Papazian
Dec 1, 2017·Medizinische Klinik, Intensivmedizin und Notfallmedizin·A PesentiT Mauri
Jul 19, 2017·Intensive Care Medicine·Thomas BeinLaurent Papazian
Jan 1, 2017·Current Anesthesiology Reports·Omar S Alibrahim, Christopher M B Heard
Jul 24, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Christina MarattaGail M Annich
Mar 13, 2021·International Anesthesiology Clinics·Lauren Van SantJessica Mitchell
Mar 16, 2021·The International Journal of Artificial Organs·Matthew L FriedmanChristopher W Mastropietro
May 11, 2021·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Sarvesh Pal Singh, Milind Padmakar Hote

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