PMID: 11910724Mar 26, 2002Paper

Mechanical ventilation in acute lung injury and ARDS. Tidal volume reduction

Critical Care Clinics
Roy G Brower

Abstract

Traditional mechanical ventilation practices used generous tidal volumes in patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS). This approach may have caused overdistention of aerated lung units, thus exacerbating lung injury in some patients. Several recent clinical trials of traditional versus lower tidal volume strategies in ALI/ARDS yielded disparate results. In the largest study, the lower tidal volume approach was associated with lower mortality and more ventilator-free days. This article reviews the rationale for tidal volume reduction in ALI/ARDS and the differences between the studies. Several different interpretations of the recent clinical trial results are addressed.

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Citations

Jun 7, 2005·Biochemical Genetics·James R McGlothlinShui Qing Ye
Apr 12, 2003·Critical Care Medicine·Roy G Brower, Gordon D Rubenfeld
Sep 22, 2007·Critical Care Medicine·Andrew Rosenberg, Kevin K Tremper
Feb 13, 2004·The Journal of Trauma·Grant V BochicchioThomas M Scalea
Dec 8, 2004·American Journal of Respiratory and Critical Care Medicine·Shui Q YeJoe G N Garcia
Aug 6, 2005·American Journal of Respiratory and Critical Care Medicine·David N HagerUNKNOWN ARDS Clinical Trials Network
Sep 17, 2005·American Journal of Respiratory Cell and Molecular Biology·Ali MallakinSusan E Waltz
Sep 15, 2009·American Journal of Respiratory Cell and Molecular Biology·Saad SammaniJoe G N Garcia
Mar 15, 2006·Current Opinion in Anaesthesiology·Karen BosmaV Marco Ranieri
Jan 3, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Naoki MiyaoKazuhiro Yamaguchi
Mar 30, 2018·Dimensions of Critical Care Nursing : DCCN·Angela Nguyen

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