Mechanical ventilation-induced oxidative stress in the diaphragm

Journal of Applied Physiology
Murat A ZergerogluScott K Powers

Abstract

Prolonged mechanical ventilation (MV) results in oxidative damage in the diaphragm; however, it is unclear whether this MV-induced oxidative injury occurs rapidly or develops slowly over time. Furthermore, it is unknown whether both soluble (cytosolic) and insoluble (myofibrillar) proteins are equally susceptible to oxidation during MV. These experiments tested two hypotheses: 1). MV-induced oxidative injury in the diaphragm occurs within the first 6 h after the initiation of MV; and 2). MV is associated with oxidative modification of both soluble and insoluble proteins. Adult Sprague-Dawley rats were randomly divided into one of seven experimental groups: 1) control (n = 8); 2) 3-h MV (n = 8); 3). 6-h MV (n = 6); 4). 18-h MV (n = 8); 5). 3-h anesthesia-spontaneous breathing (n = 8); 6). 6-h anesthesia-spontaneous breathing (n = 6); and 7). 18-h anesthesia-spontaneous breathing (n = 8). Markers of oxidative injury in the diaphragm included the measurement of reactive (protein) carbonyl derivatives (RCD) and total lipid hydroperoxides. Three hours of MV did not result in oxidative injury in the diaphragm. In contrast, both 6 and 18 h of MV promoted oxidative injury in the diaphragm, as indicated by increases in both protein RCD ...Continue Reading

References

May 1, 1992·The American Journal of Physiology·H KondoY Itokawa
Jan 1, 1990·Lung·J C Chevrolet
Jan 1, 1986·Advances in Protein Chemistry·I OhtsukiS Ebashi
Sep 1, 1974·Anesthesiology·A B Froese, A C Bryan
Jun 1, 1994·American Journal of Respiratory and Critical Care Medicine·G Le BourdellesM Aubier
Jan 1, 1994·Methods in Enzymology·A Z Reznick, L Packer
Mar 1, 1997·American Journal of Respiratory and Critical Care Medicine·A Jubran, M J Tobin
May 15, 1997·The Biochemical Journal·R T DeanM J Davies
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·L J YanR S Sohal
Feb 12, 1998·Medicine and Science in Sports and Exercise·S K PowersD Prezant
Aug 12, 1998·American Journal of Respiratory and Critical Care Medicine·T VassilakopoulosC Roussos
Oct 29, 1998·The American Journal of Physiology·S K PowersJ Jessup
Jun 9, 1999·Mechanisms of Ageing and Development·S GotoN Ishii
Mar 21, 2002·Intensive Care Medicine·Peter J RadellLars I Eriksson
Apr 19, 2002·Journal of Applied Physiology·Scott K PowersStephen L Dodd
May 17, 2002·Journal of Applied Physiology·Catherine S H SassoonGary C Sieck
May 29, 2002·Free Radical Biology & Medicine·Reshma Shringarpure, Kelvin J A Davies
Nov 8, 2002·American Journal of Respiratory and Critical Care Medicine·R Andrew ShanelyScott K Powers

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Citations

Jul 26, 2005·Intensive Care Medicine·Samir JaberStefan Matecki
Aug 30, 2005·American Journal of Respiratory and Critical Care Medicine·Keith C DeRuisseauScott K Powers
Dec 17, 2005·Critical Care : the Official Journal of the Critical Care Forum·Theodoros VassilakopoulosCharis Roussos
Nov 4, 2006·American Journal of Respiratory and Critical Care Medicine·Joseph M McClungScott K Powers
Aug 30, 2008·Journal of Applied Physiology·Chiao-nan ChenLaDora V Thompson
Sep 13, 2008·Critical Care : the Official Journal of the Critical Care Forum·Emmanuel FutierJean-Etienne Bazin
Oct 14, 2008·American Journal of Respiratory and Critical Care Medicine·Karen MaesGhislaine Gayan-Ramirez
Sep 23, 2009·Critical Care : the Official Journal of the Critical Care Forum·Catherine Sh Sassoon, Vincent J Caiozzo
Feb 6, 2010·Critical Care Medicine·Scott K PowersSanford Levine
Mar 6, 2010·Journal of Applied Physiology·Melissa A WhiddenScott K Powers
Feb 12, 2011·Journal of Applied Physiology·Ashley J SmuderScott K Powers
Apr 5, 2011·Critical Care : the Official Journal of the Critical Care Forum·Samir JaberBasil J Petrof
Sep 21, 2011·PloS One·Li-Fu LiPao-Hsien Chu
Mar 16, 2013·Advances in Nutrition·Brigitte I Frohnert, David A Bernlohr
Oct 9, 2004·American Journal of Respiratory Cell and Molecular Biology·Esther BarreiroSabah N A Hussain
May 6, 2005·Respiratory Physiology & Neurobiology·Katharine L RowleyGary C Sieck
Oct 12, 2007·Intensive Care Medicine·Theodoros Vassilakopoulos
Jan 24, 2004·American Journal of Respiratory and Critical Care Medicine·Theodoros Vassilakopoulos, Basil J Petrof
Jun 18, 2004·American Journal of Respiratory and Critical Care Medicine·Catherine S H SassoonVincent J Caiozzo
Sep 18, 2004·American Journal of Respiratory and Critical Care Medicine·Jenna L BettersScott K Powers
Oct 31, 2015·The American Journal of the Medical Sciences·Huiqing GeKejing Ying
Aug 17, 2014·The Journal of Physiology·Jessica CannavinoMaria Antonietta Pellegrino
Sep 13, 2014·Critical Care : the Official Journal of the Critical Care Forum·Catherine SassoonScott K Powers
Feb 3, 2009·Free Radical Biology & Medicine·Andreas N KavazisScott K Powers
Sep 22, 2012·Journal of Cachexia, Sarcopenia and Muscle·Anders NedergaardKim Henriksen
Feb 16, 2011·The Journal of Physiology·Maria Antonietta PellegrinoRoberto Bottinelli
Jun 15, 2010·Muscle & Nerve·Björn H SanderKonstantinos Raymondos
Oct 30, 2013·Mass Spectrometry Reviews·Esther Barreiro
Apr 8, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Li-Fu LiYung-Yang Liu
Jul 11, 2006·Respiratory Physiology & Neurobiology·Jacobo SellaresEsther Barreiro
Feb 17, 2006·Respiratory Physiology & Neurobiology·Melissa A Smith, Michael B Reid
Feb 9, 2013·Respiratory Medicine·Claire AndréjakVincent Jounieaux
Jun 3, 2014·Critical Care : the Official Journal of the Critical Care Forum·Leigh A Callahan, Gerald S Supinski
Apr 1, 2016·Journal of Cachexia, Sarcopenia and Muscle·David BergerJoerg C Schefold
Dec 9, 2016·Journal of Clinical Medicine·Bruno-Pierre Dubé, Martin Dres
Mar 2, 2012·Acta Cirúrgica Brasileira·André de Sá Braga OliveiraPaloma Lys de Medeiros
Oct 3, 2006·Critical Care Medicine·Dries TestelmansGhislaine Gayan-Ramirez

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