Mechanical ventilation of isolated septic rat lungs: effects on surfactant and inflammatory cytokines

Journal of Applied Physiology
T NakamuraR Veldhuizen

Abstract

The effects of mechanical ventilation (MV) on the surfactant system and cytokine secretion were studied in isolated septic rat lungs. At 23 h after sham surgery or induction of sepsis by cecal ligation and perforation (CLP), lungs were excised and randomized to one of three groups: 1) a nonventilated group, 2) a group subjected to 1 h of noninjurious MV (tidal volume = 10 ml/kg, positive end-expiratory pressure = 3 cmH(2)O), or 3) a group subjected to 1 h of injurious MV (tidal volume = 20 ml/kg, positive end-expiratory pressure = 0 cmH(2)O). Nonventilated sham and CLP lungs had similar compliance, normal lung morphology, surfactant, and cytokine concentrations. Injurious ventilation decreased compliance, altered surfactant, increased cytokines, and induced morphological changes compared with nonventilation in sham and CLP lungs. In these lungs, the surfactant system was similar in sham and CLP lungs; however, tumor necrosis factor-alpha and interleukin-6 levels were significantly higher in CLP lungs. We conclude that injurious ventilation altered surfactant independent of sepsis and that the CLP lungs were predisposed to the secretion of larger amounts of cytokines because of ventilation.

References

Aug 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G Enhorning
Dec 1, 1991·The Journal of Clinical Investigation·T J GregoryT M Hyers
Dec 1, 1990·Journal of Applied Physiology·J F LewisA H Jobe
Nov 1, 1984·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·F PossmayerP G Harding
Aug 1, 1980·The Journal of Surgical Research·K A WichtermanI H Chaudry
May 1, 1994·American Journal of Respiratory and Critical Care Medicine·J G MuscedereA S Slutsky
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·R A VeldhuizenJ F Lewis
Jan 1, 1996·The American Journal of Physiology·R A VeldhuizenJ F Lewis
Sep 1, 1996·American Journal of Respiratory and Critical Care Medicine·R B GoodmanT R Martin
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·Y ItoJ F Lewis
Mar 1, 1997·The Journal of Clinical Investigation·L TremblayA S Slutsky
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·J MalloyJ Lewis
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·D Dreyfuss, G Saumon
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·A S Slutsky, L N Tremblay
Aug 2, 2000·Critical Care Medicine·R A VeldhuizenA S Slutsky

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Citations

Dec 16, 2004·Critical Care Medicine·Angela M BrackenburyJames F Lewis
Sep 21, 2007·Physics in Medicine and Biology·Nancy L FordMaria Drangova
Oct 19, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michael R WilsonMasao Takata
Jan 9, 2003·Annual Review of Physiology·James F Lewis, Ruud Veldhuizen
Jan 28, 2003·Current Opinion in Critical Care·Nicholas E Vlahakis, Rolf D Hubmayr
Jun 3, 2010·The Journal of Physiology·S R McKechnie, G B Drummond
Jan 1, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nadir YehyaSusan S Margulies
Jul 15, 2015·Oxidative Medicine and Cellular Longevity·Wei XuanQingping Wu
May 23, 2006·Critical Care Medicine·Naveen Gupta, Michael A Matthay
Mar 27, 2009·Physics in Medicine and Biology·G CaoO Zhou
Feb 17, 2009·American Journal of Respiratory and Critical Care Medicine·Michael R WilsonMasao Takata
Apr 21, 2006·Critical Care Medicine·Glenn K LevineSusan S Margulies
May 15, 2004·American Journal of Respiratory and Critical Care Medicine·Tamás DolinayAugustine M K Choi
Jan 21, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Vijay P A RasaiahRuud A W Veldhuizen
Mar 17, 2009·Physics in Medicine and Biology·N L FordM Drangova
Jul 4, 2008·Critical Care Medicine·Timothy C BaileyRuud A W Veldhuizen
Oct 24, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shuhei OtaKiyoyasu Kurahashi
Nov 18, 2018·Critical Care : the Official Journal of the Critical Care Forum·Xibing DingLi-Ming Zhang
Nov 23, 2006·The Surgical Clinics of North America·Michael Donahoe

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