Mechanically activated ion channels

The International Journal of Biochemistry & Cell Biology
Boris Martinac, Kate Poole

Abstract

The ability of cells to sense and respond to their physical environment is fundamental to a broad spectrum of biological processes. Cells express an array of force sensors that can transduce mechanical inputs into biochemical signals, including the mechanically activated ion channels PIEZO1, PIEZO2 and TRPV4. The identification and characterisation of mechanically activated ion channels has proven challenging, as has identifying their mode of activation and regulation in vivo. However, the diverse channelopathies associated with the known channels highlights their physiological importance.

Citations

May 16, 2019·Cold Spring Harbor Perspectives in Biology·Sarah J Roberts-ThomsonGregory R Monteith
Dec 12, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Choon Leng SoGregory R Monteith
Jun 3, 2020·International Journal of Molecular Sciences·Jueun RohChul-Kyu Park
Apr 11, 2020·Cardiovascular Toxicology·Xiaoli JiaShizhong Zhang
May 18, 2020·Annals of Neurology·Chris DupontMark M Rich
Sep 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lu WangXiaoming Li
Feb 8, 2019·Frontiers in Pharmacology·Sara BaratchiPeter McIntyre
Feb 13, 2021·BioMed Research International·Daxue ZhuXuewen Kang
Mar 3, 2021·Archives of Oral Biology·Jeeranan ManokawinchokeHiroshi Egusa
Oct 15, 2020·Science Signaling·Roberta GualdaniPhilippe Gailly
Jul 3, 2021·International Journal of Molecular Sciences·Xia XuLifang Hu
Nov 7, 2019·ACS Nano·Navid BaviKate Poole
Sep 3, 2021·Journal of Cell Science·Aurore Claude-TaupinNicolas Dupont

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