Mechanically based generative laws of morphogenesis

Physical Biology
Lev V Beloussov

Abstract

A deep (although at the first glance naïve) question which may be addressed to embryonic development is why during this process quite definite and accurately reproduced successions of precise and complicated shapes are taking place, or why, in several cases, the result of development is highly precise in spite of an extensive variability of intermediate stages. This problem can be attacked in two different ways. One of them, up to now just slightly employed, is to formulate robust macroscopic generative laws from which the observed successions of shapes could be derived. Another one, which dominates in modern embryology, regards the development as a succession of highly precise 'micropatterns', each of them arising due to the action of specific factors, having, as a rule, nothing in common with each other. We argue that the latter view contradicts a great bulk of firmly established data and gives no satisfactory answers to the main problems of development. Therefore we intend to follow the first way. By doing this, we regard developing embryos as self-organized systems transpierced by feedbacks among which we pay special attention to those linked with mechanical stresses (MS). We formulate a hypothesis of so-called MS hyper-res...Continue Reading

References

Jul 24, 1978·Differentiation; Research in Biological Diversity·C S Lange, V E Steele
Sep 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H F Nijhout
Jan 1, 1990·Annals of the New York Academy of Sciences·J G White
Jan 1, 1990·Annals of the New York Academy of Sciences·T E Schroeder
Dec 1, 1989·The Journal of Cell Biology·T J DennerllS R Heidemann
Dec 1, 1988·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·L V BeloussovI I Naumidi
Dec 21, 1987·Journal of Theoretical Biology·B N BelintsevA G Zaraisky
Jul 30, 1981·Developmental Biology·G M OdellB Burnside
Jan 1, 1995·Dysphagia·N F Capra
Jun 1, 1993·Microscopy Research and Technique·L C NistorR Manaila
Feb 1, 1996·Developmental Biology·S F GilbertR A Raff
Aug 26, 1998·Journal of Theoretical Biology·L A Taber
Jan 23, 1999·Current Opinion in Genetics & Development·G A Wray, E Abouheif
Feb 9, 2000·Development Genes and Evolution·L V BeloussovA A Stein
Apr 18, 2000·The Journal of Cell Biology·D P KiehartR A Montague
Mar 5, 2003·Journal of Cell Science·Donald E Ingber
Mar 8, 2003·Computer Methods in Biomechanics and Biomedical Engineering·L V Beloussov, V I Grabovsky
Nov 7, 2003·Apoptosis : an International Journal on Programmed Cell Death·R GrafP Friedl
Apr 8, 2004·Developmental Cell·Rowena McBeathChristopher S Chen
Jul 21, 2004·Current Opinion in Genetics & Development·Eric Brouzés, Emmanuel Farge
May 21, 2005·Physical Review Letters·Sui HuangDonald E Ingber
Aug 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Donald E Ingber
Jan 6, 2006·Computer Methods in Biomechanics and Biomedical Engineering·L V Beloussov, V I Grabovsky
Feb 16, 2006·The International Journal of Developmental Biology·Lev V BeloussovNadezhda S Glagoleva
Feb 16, 2006·The International Journal of Developmental Biology·Elena M Cherdantseva, Vladimir G Cherdantsev
Feb 16, 2006·The International Journal of Developmental Biology·Yulia A Kraus
Feb 16, 2006·The International Journal of Developmental Biology·Larry A Taber
Apr 12, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nandan L NerurkarLarry A Taber
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Oct 13, 2006·Bio Systems·Lev V Beloussov, Vassily I Grabovsky
Jan 27, 2007·Cell·Arthur D Lander
Aug 28, 2007·Molecular and Cellular Neurosciences·Victor BorrellEduardo Soriano
Sep 1, 1975·Wilhelm Roux's Archives of Developmental Biology·V N Meshcheryakov, L V Beloussov

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Citations

Aug 3, 2012·Biomechanics and Modeling in Mechanobiology·Sagar D Joshi, Lance A Davidson
Sep 30, 2010·Annals of Biomedical Engineering·Benjamen A FilasLarry A Taber
Aug 7, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Larry A Taber
Apr 5, 2013·PloS One·William J KowalskiKerem Pekkan
Dec 10, 2013·Nature Methods·Otger CampàsDonald E Ingber
Jan 10, 2014·Journal of the Royal Society, Interface·Daniel LoboMichael Levin
Nov 23, 2013·The European Physical Journal. E, Soft Matter·L V Beloussov
Jun 12, 2012·Izvestiia Akademii nauk. Seriia biologicheskaia·L V Belousov
Dec 22, 2009·Integrative Biology : Quantitative Biosciences From Nano to Macro·Pablo Fernandez, Andreas R Bausch
Feb 10, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Marcello Barbieri
Jul 4, 2012·Bio Systems·M Cifra
May 12, 2012·Bio Systems·Ondřej Kučera, Daniel Havelka
May 23, 2012·Bio Systems·Lev V Beloussov
Nov 17, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·G Pezzulo, M Levin
Jun 14, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Matthew A WyczalkowskiLarry A Taber
Feb 9, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·E S KornikovaL V Beloussov
May 9, 2015·Biophysical Journal·Moritz MerckerAnna Marciniak-Czochra
Jun 25, 2014·Frontiers in Plant Science·Valeria Hernández-HernándezMariana Benítez
Jun 6, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Erez Braun, Kinneret Keren
Jan 30, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michael Levin
Nov 18, 2017·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Chris Fields, Michael Levin
May 24, 2017·Annual Review of Biophysics·Peter GrossStephan W Grill
Feb 27, 2017·Genesis : the Journal of Genetics and Development·Fedor M Eroshkin, Andrey G Zaraisky

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