Mechanically Enhanced Liquid Interfaces at Human Body Temperature Using Thermosensitive Methylated Nanocrystalline Cellulose

Langmuir : the ACS Journal of Surfaces and Colloids
N ScheublePeter Fischer

Abstract

The mechanical performance of materials at oil/water interfaces after consumption is a key factor affecting hydrophobic drug release. In this study, we methylated the surface of nanocrystalline cellulose (NCC) by mercerization and dimethyl sulfate exposure to produce thermosensitive biopolymers. These methylated NCC (metNCC) were used to investigate interfacial thermogelation at air/water and medium-chain triglyceride (MCT)/water interfaces at body temperature. In contrast to bulk fluid dynamics, elastic layers were formed at room temperature, and elasticity increased significantly at body temperature, which was measured by interfacial shear and dilatational rheology in situ. This unique phenomenon depends on solvent quality, temperature, and polymer concentration at interfaces. Thus, by adjusting the degree of hydrophobicity of metNCC, the interfacial elasticity and thermogelation of the interfaces could be varied. In general, these new materials (metNCC) formed more brittle interfacial layers compared to commercial methylcellulose (MC A15). Thermogelation of methylcellulose promotes attractive intermolecular forces, which were reflected in a change in self-assembly of metNCC at the interface. As a consequence, layer thickness...Continue Reading

References

Dec 6, 2000·Advanced Drug Delivery Reviews·M J Lawrence, G D Rees
Jul 14, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Yirong XuXiao Hu
Jan 18, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Baumgartner SasaKristl Julijana
Apr 2, 2010·ACS Applied Materials & Interfaces·Toshinori FujieRigoberto C Advincula
May 30, 2013·Journal of the Science of Food and Agriculture·Maelle Douaire, Ian T Norton
Jul 17, 2014·Biomacromolecules·N ScheubleP Fischer
Aug 8, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Sophia JordensRaffaele Mezzenga
Sep 27, 2014·Carbohydrate Polymers·Amelia Torcello-Gómez, Timothy J Foster
Oct 23, 2014·ACS Nano·Sophia JordensRaffaele Mezzenga

❮ Previous
Next ❯

Citations

Feb 13, 2021·Biomacromolecules·Marco BeaumontAurelien Forget
Nov 13, 2019·Biomacromolecules·Pascal BertschPeter Fischer
Aug 17, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Hua-Neng XuLianfu Zhang
May 16, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Pascal Bertsch, Peter Fischer
Aug 23, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Merel E H van den BergPeter Fischer
Nov 16, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Pascal BertschPeter Fischer
Feb 14, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Pascal BertschPeter Fischer
May 1, 2018·ACS Applied Materials & Interfaces·Nathalie ScheublePeter Fischer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.