Mechanically Gated Ion Channels in Mammalian Hair Cells

Frontiers in Cellular Neuroscience
Xufeng Qiu, Ulrich Müller

Abstract

Hair cells in the inner ear convert mechanical stimuli provided by sound waves and head movements into electrical signal. Several mechanically evoked ionic currents with different properties have been recorded in hair cells. The search for the proteins that form the underlying ion channels is still in progress. The mechanoelectrical transduction (MET) channel near the tips of stereociliary in hair cells, which is responsible for sensory transduction, has been studied most extensively. Several components of the sensory mechanotransduction machinery in stereocilia have been identified, including the multi-transmembrane proteins tetraspan membrane protein in hair cell stereocilia (TMHS)/LHFPL5, transmembrane inner ear (TMIE) and transmembrane channel-like proteins 1 and 2 (TMC1/2). However, there remains considerable uncertainty regarding the molecules that form the channel pore. In addition to the sensory MET channel, hair cells express the mechanically gated ion channel PIEZO2, which is localized near the base of stereocilia and not essential for sensory transduction. The function of PIEZO2 in hair cells is not entirely clear but it might have a role in damage sensing and repair processes. Additional stretch-activated channels o...Continue Reading

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Citations

Dec 28, 2019·G3 : Genes - Genomes - Genetics·Albert Erives, Bernd Fritzsch
Feb 23, 2020·Annual Review of Neuroscience·Peng JinYuh-Nung Jan
Sep 11, 2019·Biophysics Reviews·Ece BayirYannis F Missirlis
Apr 7, 2020·Nucleic Acids Research·Lingyan WangJohn V Brigande
May 25, 2021·IScience·Nicholas Boyd-GibbinsJoerg T Albert
Nov 10, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Kaitian ChenGuanxia Xiong
Dec 9, 2021·Tissue Engineering. Part a·Gaston OtarolaKyriacos A Athanasiou

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Methods Mentioned

BETA
two-hybrid
co-immunoprecipitation

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