Mechanically induced electrical potentials of articular cartilage

Journal of Biomechanics
B Schmidt-RohlfingJiri Silny

Abstract

While there is increasing evidence that chondrocytes are affected by mechanically induced stimuli, endogenous force-related electrical potentials within articular cartilage have been so far observed only in-vitro. Using a porcine ex-vivo model (German Land Race), 8 knee joints were explanted and exposed to mechanical force (up to 800 N) using a special device. Electrodes were inserted into the cartilage matrix. With an amplifier and an A/D transducer the changes of electrical voltage between the electrodes as well as those of the force were recorded online and simultaneously on a computer. Additionally, we located one pair of electrodes on the surface of the cartilage tissue to detect electrical fields outside the cartilage tissue. In relation to the applied force we observed that electrical potentials derived from inside and outside the articular cartilage showed a correspondence. When an alternating force with an amplitude of 360 N and a frequency of about 0.2 Hz was periodically applied, we measured peak amplitudes ranging from 2.1 to 5.5 mV within the cartilage tissue with electrical negativity within the weight bearing area of the cartilage tissue. The measured voltages depended on the applied force, the location of the el...Continue Reading

References

May 1, 1992·Trends in Biochemical Sciences·J E ScottA Linker
Aug 1, 1991·Journal of Biomechanical Engineering·W M LaiV C Mow
Jan 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A C HallK A Gehl
Jan 1, 1988·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·I KivirantaH J Helminen
Jan 1, 1987·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·E H FrankD R Eyre
Dec 1, 1972·Science·C A Bassett, R J Pawluk
Apr 13, 1968·Nature·J C Anderson, C Eriksson
Jan 21, 1967·Nature·M H Shamos, L S Lavine
Feb 1, 1980·Journal of Biomechanical Engineering·V C MowC G Armstrong
Feb 1, 1995·Arthritis and Rheumatism·L J BonassarA J Grodzinsky

❮ Previous
Next ❯

Citations

Apr 5, 2008·Rheumatology International·Bernhard Schmidt-RohlfingKarsten Gavenis
Aug 10, 2010·BMC Complementary and Alternative Medicine·Karsten GavénisUlrich Schneider
Jan 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Stephen LumayagShunbin Xu
Nov 12, 2013·European Journal of Public Health·Lucía ArtazcozCarme Borrell
Jan 15, 2014·Scientific Reports·Xiaoning YuanGordana Vunjak-Novakovic
Jun 24, 2014·IEEE Transactions on Bio-medical Engineering·Qingyi HanPierre Savard
May 20, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·T A BanksJ J Cooper-White
Feb 21, 2006·Biochemical and Biophysical Research Communications·Carl T BrightonCharles C Clark
Feb 13, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jill-Desiree BredersonSteve McGaraughty
Apr 3, 2008·The Journal of Bone and Joint Surgery. American Volume·Carl T BrightonCharles C Clark
Oct 14, 2004·Clinical Orthopaedics and Related Research·Wei WangCarl T Brighton
Nov 17, 2005·Journal of Medical Engineering & Technology·B Schmidt-RohlfingJ Silny
Jan 7, 2021·International Journal of Molecular Sciences·Simone KruegerRainer Bader

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.