Mechanics of a fiber network within a non-fibrillar matrix: model and comparison with collagen-agarose co-gels.

Annals of Biomedical Engineering
Spencer P LakeVictor H Barocas

Abstract

While collagen is recognized as the predominant mechanical component of soft connective tissues, the role of the non-fibrillar matrix (NFM) is less well understood. Even model systems, such as the collagen-agarose co-gel, can exhibit complex behavior, making it difficult to identify relative contributions of specific tissue constituents. In the present study, we developed a two-component microscale model of collagen-agarose tissue analogs and used it to elucidate the interaction between collagen and NFM in uniaxial tension. Collagen fibers were represented with Voronoi networks, and the NFM was modeled as a neo-Hookean solid. Model predictions of total normal stress and Poisson's ratio matched experimental observations well (including high Poisson's values of ~3), and the addition of NFM led to composition-dependent decreases in volume change and increases in fiber stretch. Because the NFM was more resistant to volume change than the fiber network, extension of the composite led to pressurization of the NFM. Within a specific range of parameter values (low shear modulus and moderate Poisson's ratio), the magnitude of the reaction force decreased relative to this pressurization component resulting in a negative (compressive) NFM...Continue Reading

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Citations

Mar 1, 2013·Journal of Biomechanical Engineering·Mohammad F Hadi, Victor H Barocas
May 31, 2013·Journal of Biomechanical Engineering·Victor K LaiVictor H Barocas
Jan 23, 2016·Cytotherapy·Ramkumar Tiruvannamalai AnnamalaiJan P Stegemann
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Sep 8, 2015·Biomechanics and Modeling in Mechanobiology·Tao Jin, Ilinca Stanciulescu
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Nov 29, 2016·Journal of Biomechanical Engineering·Colleen M WitzenburgVictor H Barocas
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Nov 20, 2014·Annals of Biomedical Engineering·Lazarina GyonevaVictor H Barocas
May 7, 2016·Annals of Biomedical Engineering·Victor K LaiVictor H Barocas
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Nov 21, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Xiaogang WangDavid M Pierce
Oct 15, 2021·Soft Matter·Fuad HasanAshfaq Adnan

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