PMID: 6414281Oct 1, 1983Paper

Mechanics of pulsus alternans in aortic valve stenosis

The American Journal of Cardiology
W K LaskeyN Reichek

Abstract

Differences in the mechanics of strong and weak contractions during sustained pulsus alternans were studied in 4 patients with aortic valve stenosis (AS). No significant difference was observed between strong (S) and weak (W) beats in M-mode echographic end-diastolic minor-axis dimension or end-diastolic meridional wall stress. Peak systolic meridional stress (S:225 X 10(3) dynes/cm2; W:205 X 10(3) dynes/cm2), the time integral of left ventricular (LV) meridional systolic stress (S:5,000 X 10(3) dynes/cm2; W:4,500 X 10(3) dynes/cm2) and the area of a stress dimension loop (S:202 X 10(3) dyne/cm; W 165 X 10(3) dyne/cm) were all greater for strong beats. However, end-systolic meridional stress (S:100 X 10(3) dynes/cm2; W:115 X 10(3) dynes/cm2) and end-systolic minor-axis dimension (S:4.75 cm; W:5.0 cm) were significantly greater for weak beats. Stress-length relations, derived from resting and postnitroglycerin determinations, revealed higher end-systolic dimensions for weak beats at any level of limiting afterload, suggesting diminished contractile performance of weak beats. Additionally, fractional minor-axis shortening for weak beats was diminished, at any level of end-systolic stress, in comparison with that for strong beats....Continue Reading

References

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Citations

Apr 16, 1998·Catheterization and Cardiovascular Diagnosis·M J Kern
Dec 1, 1991·Catheterization and Cardiovascular Diagnosis·W J SchoenM J Kern
Mar 1, 1992·Catheterization and Cardiovascular Diagnosis·M J KernT C Hilton
Feb 1, 1994·Catheterization and Cardiovascular Diagnosis·E A CaraccioloM J Kern
Jun 1, 1992·Mathematical Biosciences·G Fruchter, S Ben-Haim
Aug 1, 1992·Journal of the American College of Cardiology·B Surawicz, C Fisch
May 1, 1985·Journal of the American College of Cardiology·K M Kessler
Dec 1, 2009·Cardiology Research and Practice·Param Vidwan, George A Stouffer
Jun 1, 1988·American Heart Journal·S SchaeferG J Dehmer
Jan 21, 1991·Journal of Theoretical Biology·G Fruchter, S Ben-Haim
Sep 1, 1984·The American Journal of Cardiology·W K LaskeyN Reichek
Jan 1, 1990·Critical Reviews in Food Science and Nutrition·G M Roy

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