Mechanism and color modulation of fungal bioluminescence

Science Advances
Zinaida M KaskovaIlia V Yampolsky

Abstract

Bioluminescent fungi are spread throughout the globe, but details on their mechanism of light emission are still scarce. Usually, the process involves three key components: an oxidizable luciferin substrate, a luciferase enzyme, and a light emitter, typically oxidized luciferin, and called oxyluciferin. We report the structure of fungal oxyluciferin, investigate the mechanism of fungal bioluminescence, and describe the use of simple synthetic α-pyrones as luciferins to produce multicolor enzymatic chemiluminescence. A high-energy endoperoxide is proposed as an intermediate of the oxidation of the native luciferin to the oxyluciferin, which is a pyruvic acid adduct of caffeic acid. Luciferase promiscuity allows the use of simple α-pyrones as chemiluminescent substrates.

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Citations

Jul 28, 2017·The Journal of Physical Chemistry. B·Luís Pinto da SilvaJoaquim C G Esteves da Silva
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Datasets Mentioned

BETA
MB519818

Methods Mentioned

BETA
column chromatography
NMR

Software Mentioned

Agilent Cary Eclipse
Gaussian

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