Mechanism and regulation of the nonsense-mediated decay pathway

Nucleic Acids Research
Nele HugJavier F Cáceres

Abstract

The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs) but also regulates the abundance of a large number of cellular RNAs. The central role of NMD in the control of gene expression requires the existence of buffering mechanisms that tightly regulate the magnitude of this pathway. Here, we will focus on the mechanism of NMD with an emphasis on the role of RNA helicases in the transition from NMD complexes that recognize a PTC to those that promote mRNA decay. We will also review recent strategies aimed at uncovering novel trans-acting factors and their functional role in the NMD pathway. Finally, we will describe recent progress in the study of the physiological role of the NMD response.

References

May 1, 1992·Molecular and Cellular Biology·P LeedsM R Culbertson
Mar 1, 1990·Genes & Development·N A WoychikR A Young
Oct 1, 1993·Genes & Development·R Pulak, P Anderson
Jun 17, 1998·The EMBO Journal·R ThermannA E Kulozik
Feb 15, 2001·Nature Structural Biology·B Schwer
Apr 30, 2003·Molecular Cell·Niels H GehringAndreas E Kulozik
Oct 19, 2004·Genome Research·Jean-François RualMarc Vidal
Nov 18, 2004·Molecular Cell·Leonie Unterholzner, Elisa Izaurralde
Apr 16, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Claudio R Alonso
Aug 9, 2005·Nature Structural & Molecular Biology·Handan Kaygun, William F Marzluff
Sep 20, 2005·Nature Structural & Molecular Biology·Lionel BallutHervé Le Hir
Dec 13, 2005·Gene·Olivier CordinPatrick Linder
Feb 2, 2006·Molecular and Cellular Biology·Jürgen WittmannHans-Martin Jäck
Feb 21, 2006·Current Biology : CB·Claus M Azzalin, Joachim Lingner
Apr 20, 2006·Nature Structural & Molecular Biology·Marc BühlerOliver Mühlemann
May 26, 2006·Nature Reviews. Molecular Cell Biology·Nadia AmraniAllan Jacobson
Aug 26, 2006·Science·Christian B F AndersenGregers Rom Andersen
Aug 29, 2006·Nucleic Acids Research·Eckhard Jankowsky, Heath Bowers
Jan 2, 2007·PLoS Genetics·Mark M Metzstein, Mark A Krasnow
Mar 14, 2007·Annual Review of Biochemistry·Yao-Fu ChangMiles F Wilkinson
Mar 17, 2007·The EMBO Journal·Wai-Kin ChanMiles F Wilkinson
Mar 22, 2007·PloS One·Christian G Noble, Haiwei Song
Apr 18, 2007·Genes & Development·Dasa LongmanJavier F Cáceres
Aug 3, 2007·Genes & Development·Olaf Isken, Lynne E Maquat

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Citations

May 18, 2016·Trends in Genetics : TIG·Saverio BrognaMarija Petric
Jun 5, 2016·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Zohar ZafrirTamir Tuller
Jul 21, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Fursham M Hamid, Eugene V Makeyev
Aug 19, 2016·Nucleic Acids Research·Michelle HussongMichal R Schweiger
Jul 5, 2016·Human Mutation·Atteeq U RehmanThomas B Friedman
Sep 7, 2016·Biochimica Et Biophysica Acta·Vivek Kumar Raxwal, Karel Riha
Oct 8, 2016·Autophagy·Lisa B FrankelAnders H Lund
Nov 8, 2016·American Journal of Human Genetics·Gali HeimerSusan J Hayflick
Sep 30, 2016·Journal of Cellular Physiology·María Laura MatosMónica Hebe Vazquez-Levin
Mar 31, 2017·Proceedings of the National Academy of Sciences of the United States of America·Yoshiaki ItoHiroshi Asahara
Mar 31, 2017·Journal of Medicinal Chemistry·Masahiro ItoYasuhiro Imaeda
Mar 18, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Andrew R Bassett
Dec 23, 2017·Nucleic Acids Research·Xin HanTangliang Li
Jan 15, 2018·Cellular and Molecular Life Sciences : CMLS·Udit Dalwadi, Calvin K Yip
Mar 7, 2018·Wiley Interdisciplinary Reviews. RNA·David Rekosh, Marie-Louise Hammarskjold
Jul 25, 2017·Journal of Medical Genetics·Ilse MeerschautBert Callewaert
Sep 27, 2018·Critical Reviews in Biochemistry and Molecular Biology·Yu-Hang Xing, Ling-Ling Chen
Jan 18, 2018·Journal of Human Genetics·Kazuhiro IwamaNaomichi Matsumoto
Apr 27, 2019·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Pavlina SkalickaPetra Liskova
Dec 16, 2017·Nature Reviews. Cancer·Vladimir J N BykovKlas G Wiman
May 22, 2019·Plant & Cell Physiology·Misato Ohtani, Andreas Wachter
Apr 13, 2018·The EMBO Journal·Da LinChristopher A O'Callaghan
Aug 10, 2019·Clinical Genetics·Jameson PatakRobert R Lebel
Aug 2, 2017·Annual Review of Cell and Developmental Biology·Serge PlazaFrançois Payre
Dec 29, 2019·Wiley Interdisciplinary Reviews. RNA·Cornelia KilchertMinna-Liisa Änkö
Nov 16, 2019·Cell Research·Li ZhuYanhui Xu
Jan 25, 2020·Journal of Clinical Medicine·Monica BorgattiNicola Altamura

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