Mechanism-Based Condition Screening for Sustainable Catalysis in Single-Electron Steps by Cyclic Voltammetry

Angewandte Chemie
Theresa LiedtkeAndreas Gansäuer

Abstract

A cyclic-voltammetry-based screening method for Cp2 TiX-catalyzed reactions is introduced. Our mechanism-based approach enables the study of the influence of various additives on the electrochemically generated active catalyst Cp2 TiX, which is in equilibrium with catalytically inactive [Cp2 TiX2 ]- . Thioureas and ureas are most efficient in the generation of Cp2 TiX in THF. Knowing the precise position of the equilibrium between Cp2 TiX and [Cp2 TiX2 ]- allowed us to identify reaction conditions for the bulk electrolysis of Cp2 TiX2 complexes and for Cp2 TiX-catayzed radical arylations without having to carry out the reactions. Our time- and resource-efficient approach is of general interest for the design of catalytic reactions that proceed in single-electron steps.

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Citations

Jan 8, 2019·Chemistry : a European Journal·Leonardus H LeijendekkerJan Streuff
Aug 9, 2019·Angewandte Chemie·Felix MühlhausAndreas Gansäuer
Mar 28, 2020·Angewandte Chemie·Andreas GansäuerRobert A Flowers
Aug 28, 2020·Chemical Society Reviews·Manfred Manßen, Laurel L Schafer
May 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sofia StrekalovaYulia Budnikova
Aug 2, 2019·Chemical Science·Christopher SandfordShelley D Minteer
Jun 2, 2021·Chemical Society Reviews·Luiz F T NovaesSong Lin
Oct 28, 2019·The Journal of Organic Chemistry·Terry McCallumSong Lin
Nov 5, 2020·The Journal of Organic Chemistry·Antonio Rosales MartínezIgnacio Rodríguez-García
Mar 22, 2019·Journal of the American Chemical Society·Elliot P FarneyTehshik P Yoon
Dec 1, 2021·Angewandte Chemie·Dina Schwarz G HenriquesAndreas Gansäuer

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