Mechanism-Based Modeling of Tumor Growth and Treatment Response Constrained by Multiparametric Imaging Data

JCO Clinical Cancer Informatics
David HormuthThomas E Yankeelov

Abstract

Multiparametric imaging is a critical tool in the noninvasive study and assessment of cancer. Imaging methods have evolved over the past several decades to provide quantitative measures of tumor and healthy tissue characteristics related to, for example, cell number, blood volume fraction, blood flow, hypoxia, and metabolism. Mechanistic models of tumor growth also have matured to a point where the incorporation of patient-specific measures could provide clinically relevant predictions of tumor growth and response. In this review, we identify and discuss approaches that use multiparametric imaging data, including diffusion-weighted magnetic resonance imaging, dynamic contrast-enhanced magnetic resonance imaging, diffusion tensor imaging, contrast-enhanced computed tomography, [18F]fluorodeoxyglucose positron emission tomography, and [18F]fluoromisonidazole positron emission tomography to initialize and calibrate mechanistic models of tumor growth and response. We focus the discussion on brain and breast cancers; however, we also identify three emerging areas of application in kidney, pancreatic, and lung cancers. We conclude with a discussion of the future directions for incorporating multiparametric imaging data and mechanisti...Continue Reading

References

Apr 23, 2004·Neuroradiology·P C SundgrenR Welsh
Aug 10, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Saâd JbabdiHabib Benali
Oct 19, 2005·IEEE Transactions on Medical Imaging·Olivier ClatzNicholas Ayache
Apr 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Manfred KaufmannGunter von Minckwitz
Jan 6, 2007·Journal of Neuropathology and Experimental Neurology·Hana L P HarpoldKristin R Swanson
May 23, 2007·AJR. American Journal of Roentgenology·Dow-Mu Koh, David J Collins
Jun 5, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Susanne Martina EschmannRoland Bares
Nov 21, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jan J W LagendijkUulke A van der Heide
Nov 21, 2007·Journal of Mathematical Biology·Cosmina HogeaGeorge Biros
Feb 12, 2008·Physics in Medicine and Biology·Pierre-Yves BondiauNicholas Ayache
Feb 15, 2008·Nature Reviews. Cancer·Alexander R A Anderson, Vito Quaranta
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Feb 4, 2009·Neoplasia : an International Journal for Oncology Research·Anwar R PadhaniPeter L Choyke
Jul 17, 2009·IEEE Transactions on Medical Imaging·Ender KonukogluNicholas Ayache
Oct 16, 2009·Current Medical Imaging Reviews·Thomas E Yankeelov, John C Gore
Mar 12, 2010·Seminars in Radiation Oncology·Di Yan
Apr 8, 2010·Physics in Medicine and Biology·Nkiruka C AtuegwuThomas E Yankeelov
Sep 17, 2010·Journal of Digital Imaging·Daniel KorenblumChris Beaulieu
Feb 24, 2011·IEEE Transactions on Bio-medical Engineering·Xinjian ChenJianhua Yao
Apr 30, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Craig J GalbánBrian D Ross
Oct 1, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nkiruka C AtuegwuThomas E Yankeelov
Dec 14, 2011·Medical Image Analysis·Parisa MosayebiMartin Jagersand
May 25, 2012·The British Journal of Radiology·J P B O'ConnorA Jackson
Oct 11, 2012·IEEE Transactions on Bio-medical Engineering·Xinjian ChenJianhua Yao
Nov 21, 2012·Nature Reviews. Clinical Oncology·David A Jaffray
Jan 11, 2013·BMC Bioinformatics·Carlo BiancaMarzio Pennisi
Apr 9, 2013·Frontiers in Oncology·A L BaldockK R Swanson
Apr 12, 2013·Frontiers in Oncology·Andrea Hawkins-DaarudKristin R Swanson
May 31, 2013·Science Translational Medicine·Thomas E YankeelovVito Quaranta
Aug 13, 2013·CNS Oncology·Kathleen M Schmainda
Mar 13, 2014·Medical Image Analysis·Yixun LiuJianhua Yao
Apr 9, 2014·IEEE Transactions on Medical Imaging·Hongmei MiSu Ruan
Apr 29, 2014·Translational Oncology·Thomas L ChenevertBrian D Ross
Jul 26, 2014·Journal of Mathematical Biology·Angela M JarrettM Yousuff Hussaini
Aug 13, 2014·Nature Reviews. Clinical Oncology·Thomas E YankeelovC Chad Quarles
Dec 30, 2014·Journal of the Royal Society, Interface·Russell C RockneKristin R Swanson
Jan 17, 2015·Cancer Research·Thomas E YankeelovErin C Rericha
Mar 25, 2015·NMR in Biomedicine·Matthew Grech-SollarsChris A Clark

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Citations

Apr 27, 2019·JCO Clinical Cancer Informatics·Russell C Rockne, Jacob G Scott
Jul 3, 2019·Journal of Magnetic Resonance Imaging : JMRI·Megan E PoormanKathryn E Keenan
Jul 27, 2021·PLoS Computational Biology·Jessica L KingsleyKatarzyna A Rejniak

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