Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project

Toxicology in Vitro : an International Journal Published in Association with BIBRA
M José Gómez-LechónM T Donato

Abstract

The 6th European Framework Programme project LIINTOP was specifically raised to optimise and provide established protocols and experimental in vitro models for testing intestinal and liver absorption, metabolism and toxicity of molecules of pharmacological interest. It has been focused on some of the most promising existing liver and intestine in vitro models with the aim of further improving their performance and thus taking them to a pre-normative research stage. Regarding the specific area of the liver, a first basic approach was the optimisation of in vitro hepatic models and the development and optimisation of in vitro approaches for toxicity screening. New advanced technologies have been proposed and developed in order to determine cellular and molecular targets as endpoints of drug exposure. A key issue in the development and optimisation of in vitro hepatotoxicity screening methods was the selection of structurally diverse suitable hepatotoxic reference model compounds to be tested. To this end, a number of solid selection criteria were defined (drugs preferably than chemical agents, well-documented hepatotoxicity in man and well-defined mechanism/s of hepatotoxicity, commercially available no volatile compounds with un...Continue Reading

References

Jan 1, 1995·Pharmacology & Therapeutics·B Fromenty, D Pessayre
Jan 1, 1997·Toxicologic Pathology·W H Halliwell
Oct 13, 2000·Regulatory Toxicology and Pharmacology : RTP·H OlsonA Heller
Jan 29, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·María José Gómez-LechónRamiro Jover
Sep 5, 2002·Environmental and Molecular Mutagenesis·M Vijayaraj ReddySheila M Galloway
Jan 1, 2003·Biochimica Et Biophysica Acta·Andreas GeierCarsten Gartung
Feb 4, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Irene D RománRoger Coleman
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Philippe LettéronDominique Pessayre
Aug 2, 2003·The New England Journal of Medicine·William M Lee
Mar 23, 2004·Annals of the New York Academy of Sciences·George E N KassRichard H Hinton
Aug 28, 2004·Clinics in Liver Disease·Michael W Bradbury, Paul D Berk
Sep 15, 2004·Toxicology·Carlos M Palmeira, Anabela P Rolo
Dec 8, 2004·Current Topics in Medicinal Chemistry·Costas Ioannides, David F V Lewis
Apr 5, 2005·Toxicologic Pathology·John M Cullen
Apr 5, 2005·Toxicologic Pathology·Donna M DambachFrederic Moulin
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·B Kevin ParkDominic P Williams
Jul 6, 2005·Toxicology and Applied Pharmacology·Kevin ParkMunir Pirmohamed
Aug 2, 2005·Journal of Pediatric Gastroenterology and Nutrition·Ronald J SokolEric Gumpricht
Jan 18, 2006·Archives of Toxicology·Helmut GreimRolf Schulte-Hermann
Apr 28, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·James HynesYvonne Will
Jun 16, 2006·Expert Opinion on Drug Safety·Mark J ReasorRoger G Ulrich
Aug 8, 2006·Chemico-biological Interactions·George E N Kass
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christiane Pauli-Magnus, Peter J Meier
Oct 31, 2006·Drug Metabolism and Pharmacokinetics·Yasuhiro Masubuchi
Jun 2, 2007·Expert Opinion on Drug Metabolism & Toxicology·Wei Tang
Jun 15, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Paul NioiRonald D Snyder
Feb 5, 2008·Clinics in Liver Disease·Gernot Zollner, Michael Trauner
Apr 16, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ping KangJames A Nieman
Aug 12, 2008·Current Medicinal Chemistry·María José Gómez-LechónMaría Teresa Donato
Sep 13, 2008·Molecular Aspects of Medicine·Liyun Yuan, Neil Kaplowitz
Jan 20, 2009·Current Drug Safety·Cláudia V PereiraPaulo J Oliveira
Mar 7, 2009·Nucleic Acids Research·Inna ShokolenkoMikhail F Alexeyev
Aug 4, 2009·Chemico-biological Interactions·M Teresa DonatoM José Gómez-Lechón

❮ Previous
Next ❯

Citations

Jan 29, 2014·Archives of Toxicology·Marta BenetRamiro Jover
Dec 11, 2013·Environmental Toxicology and Pharmacology·Deepa K IngawaleSuresh R Naik
Nov 15, 2014·Archives of Toxicology·Paul JenningsJeffrey S Wiseman
Feb 15, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laia TolosaM José Gómez-Lechón
Oct 10, 2014·Expert Opinion on Drug Metabolism & Toxicology·M José Gómez-LechónM Teresa Donato
Dec 6, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Laia TolosaM José Gómez-Lechón
May 3, 2015·Toxicology Letters·Takafumi TomidaYoshihiro Konno
May 22, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laia TolosaRamiro Jover
May 22, 2016·Nucleic Acids Research·Junko YamaneWataru Fujibuchi
Jun 7, 2016·Scientific Reports·Juan Carlos García-CañaverasAgustín Lahoz
Aug 3, 2016·Journal of Applied Toxicology : JAT·Takafumi TomidaYoshihiro Konno
Nov 26, 2011·Journal of Biomolecular Screening·M Teresa DonatoM José Gómez-Lechón
May 18, 2017·Electrophoresis·Juan Carlos García-CañaverasAgustín Lahoz
Oct 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qiongyin FanAnlong Xu
Nov 30, 2018·Journal of Veterinary Science·Nga T T ThamHyun-Ok Ku
Jul 23, 2011·Alternatives to Laboratory Animals : ATLA·Arnhild SchrageRobert Landsiedel
Jun 3, 2015·Electrophoresis·Juan Carlos García-CañaverasAgustín Lahoz
Sep 15, 2017·The Journal of Toxicological Sciences·Takafumi TomidaMasahiro Iwaki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here