Mechanism for mouse strain differences in the protective effect of Sudan III against the in vivo genotoxicity of 7,12-dimethylbenz[a]anthracene

Toxicology Letters
S HatakeyamaS Fujita

Abstract

The effect of Sudan III-pretreatment on the in vivo genotoxicity of 7,12-dimethylbenz[a]anthracene (DMBA) was investigated using C57BL/6 (B6) and DBA/2 (D2) mice. A significant increase in the frequency of micronucleated reticulocytes was observed in both strains of mice treated with DMBA. The increase was significantly reduced in B6 but not D2 mice by Sudan III-pretreatment. However, enhancement of metabolic activation was found in the Ames assay in the hepatic post-mitochondrial supernatant fraction (S9) from Sudan III-treated animals. It was greater with S9 from B6 than S9 from the D2 group. When the assay was performed in the presence of glutathione, this enhancement was significantly reduced. Sudan III induced some drug metabolizing enzymes, mainly CYP1A and glutathione S-transferase was also induced. The induction of CYP1A was more effective in B6 than D2 mice. These results support our hypothesis that the simultaneous induction of Phase I and II drug metabolizing enzymes is the mechanism for the chemoprevention by Sudan III and suggest that strong induction of CYP1A might be essential for a protective effect.

References

Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·C B HugginsA Russo
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jan 1, 1989·Critical Reviews in Toxicology·D W Nebert
Nov 1, 1985·Biochemical Pharmacology·S FujitaK Kitani
Feb 9, 1973·Nature·N Haran-Chera, A Peled
Apr 1, 1974·Journal of the National Cancer Institute·C B HugginsC C Bird
Jan 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·C B Huggins, T Sugiyama
May 1, 1970·Mutation Research·M A Kastenbaum, K O Bowman
May 1, 1983·Mutation Research·D M Maron, B N Ames
Feb 1, 1984·Chemico-biological Interactions·S FujitaT Suzuki
Oct 1, 1982·Mutation Research·M HayashiM Ishidate
Apr 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·C HUGGINS, J PATAKI

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Citations

Mar 26, 2005·Brain Research. Molecular Brain Research·Richard Jay Smeyne, Vernice Jackson-Lewis
Nov 26, 2008·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Maria A Mena, Justo García de Yébenes
May 28, 2005·Glia·Michelle SmeyneRichard J Smeyne

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