Mechanism for optimization of signal-to-noise ratio of dopamine release based on short-term bidirectional plasticity

Brain Research
Claudio Da CunhaCharles D Blaha

Abstract

Repeated electrical stimulation of dopamine (dopamine) fibers can cause variable effects on further dopamine release; sometimes there are short-term decreases while in other cases short-term increases have been reported. Previous studies have failed to discover what factors determine in which way dopamine neurons will respond to repeated stimulation. The aim of the present study was therefore to investigate what determines the direction and magnitude of this particular form of short-term plasticity. Fixed potential amperometry was used to measure dopamine release in the nucleus accumbens in response to two trains of electrical pulses administered to the ventral tegmental area of anesthetized mice. When the pulse trains were of equal magnitude we found that low magnitude stimulation was associated with short-term suppression and high magnitude stimulation with short-term facilitation of dopamine release. Secondly, we found that the magnitude of the second pulse train was critical for determining the sign of the plasticity (suppression or facilitation), while the magnitude of the first pulse train determined the extent to which the response to the second train was suppressed or facilitated. This form of bidirectional plasticity m...Continue Reading

References

Sep 3, 1976·Brain Research·D H VersteegM Palkovits
Mar 1, 1996·Journal of Neuroscience Methods·E J Tehovnik
Mar 14, 1997·Science·W SchultzP R Montague
Jun 11, 1999·Neuroscience·P RedgraveK Gurney
Sep 6, 2000·The European Journal of Neuroscience·M Benoit-MarandF Gonon
Jan 25, 2002·The International Journal of Neuropsychopharmacology·M S GevaerdC Da Cunha
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·P Read MontagueR Mark Wightman
Jun 9, 2004·Methods : a Companion to Methods in Enzymology·Marie-Françoise Suaud-Chagny
Aug 1, 2007·Journal of Neurochemistry·Justin M KitaR Mark Wightman
Nov 4, 2008·Behavioural Brain Research·Claudio Da CunhaEdmar Miyoshi
Jun 29, 2010·Trends in Pharmacological Sciences·Caline S KaramJonathan A Javitch
Oct 15, 2010·Nature Reviews. Neuroscience·Peter RedgraveJose A Obeso
Sep 24, 2011·Neuroscience·M E RiceS J Cragg
Aug 29, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Etienne C HirschSerge Przedborski
Oct 20, 2012·Reviews in the Neurosciences·Claudio Da CunhaCharles D Blaha
Jan 16, 2013·The Journal of Physiology·Sten GrillnerMarcus Stephenson-Jones
Feb 17, 2015·Neuroscience and Biobehavioral Reviews·Claudio Da CunhaCharles D Blaha

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