Mechanism for Synthetic Lethality in BRCA-Deficient Cancers: No Longer Lagging Behind

Molecular Cell
Niek van Wietmarschen, Andre Nussenzweig

Abstract

Two recent studies implicate PARP as sensors of incompletely processed Okazaki fragments, changing our view about how single-strand breaks arise in unperturbed cells. Unligated Okazaki fragments may trigger homologous recombination-mediated repair and underpin genome instability in BRCA1/BRCA2-deficient cancers.

Citations

Jan 26, 2021·Experimental & Molecular Medicine·Dae-Seok KimW Lee Kraus

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