PMID: 11333842May 3, 2001Paper

Mechanism for the increase in plasma triacylglycerol concentrations after consumption of short-term, high-carbohydrate diets

The American Journal of Clinical Nutrition
B Mittendorfer, L S Sidossis

Abstract

High-carbohydrate (HC) diets are recommended for lowering the risk of coronary heart disease because they decrease plasma LDL-cholesterol concentrations. However, an unfavorable effect of HC diets is an increase in plasma triacylglycerol concentrations. The underlying mechanisms of this effect are still unclear. We examined the effect of diet composition on VLDL-triacylglycerol metabolism using in vivo isotopically labeled VLDL-triacylglycerol tracers. Six healthy subjects were studied on 2 occasions: after 2 wk of an HC diet (75% carbohydrates, 10% fat, and 15% protein) and after 2 wk of an isoenergetic high-fat (HF) diet (30% carbohydrates, 55% fat, and 15% protein). The plasma VLDL-triacylglycerol concentration was higher after the HC diet than after the HF diet (690 +/- 186 compared with 287 +/- 104 micromol/L; P < 0.05) because of higher rates of VLDL-triacylglycerol production (0.76 +/- 0.12 compared with 0.45 +/- 0.15 micromol x kg(-1) x min(-1); P < 0.05) rather than diminished VLDL-triacylglycerol clearance (1.5 +/- 0.5 compared with 1.7 +/- 0.5 mL x kg(-1) x min(-1) after the HC diet than after the HF diet, respectively). The increase in VLDL-triacylglycerol production was probably mediated by a decrease in hepatic fa...Continue Reading

References

Apr 1, 1976·The Journal of Clinical Endocrinology and Metabolism·H GinsbergG M Reaven
Jan 1, 1991·Advances in Experimental Medicine and Biology·O L FranconeG Griffaton
Jan 1, 1991·Journal of Applied Physiology·M HargreavesE A Richter
Jun 1, 1988·American Journal of Epidemiology·D S FreedmanJ J Barboriak
Mar 20, 1986·The New England Journal of Medicine·S M Grundy
Apr 1, 1968·The Journal of Clinical Investigation·H J Fallon, E L Kemp
Nov 1, 1965·The Journal of Clinical Investigation·G M ReavenJ W Farquhar
Aug 15, 1981·The Biochemical Journal·A D KalopissisX L Liepvre
Jan 1, 1995·The Journal of Clinical Investigation·L S SidossisR R Wolfe
Nov 15, 1996·The Journal of Clinical Investigation·L S SidossisR R Wolfe
Feb 1, 1997·Journal of the American College of Nutrition·K M BehallJ Hallfrisch
Jun 1, 1997·Current Opinion in Lipidology·G F Lewis
Aug 1, 1997·The American Journal of Clinical Nutrition·P SchrauwenK R Westerterp
Jan 24, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S P Brooks, B J Lampi
Jun 5, 1999·The American Journal of Cardiology·M A Austin
Oct 19, 1999·The Journal of Clinical Investigation·E J ParksM K Hellerstein

❮ Previous
Next ❯

Citations

Jul 23, 2002·The Proceedings of the Nutrition Society·Elizabeth J Parks, Elizabeth J Parks
Aug 5, 2003·Journal of Lipid Research·Dominique LetexierMichel Beylot
Dec 21, 2004·Journal of Applied Physiology·Jeffrey F HorowitzMatthew P Harber
Jun 5, 2007·Arquivos brasileiros de endocrinologia e metabologia·Viviane O Polacow, Antonio H Lancha Junior
Apr 11, 2008·The American Journal of Clinical Nutrition·Rachel RobertsKeith N Frayn
May 7, 2010·Inflammation·Adaliene Versiani Matos FerreiraLeida Maria Botion
May 26, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Zhen ZhangDing Zhi Fang
Mar 29, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Timothy D HedenJohn P Thyfault
May 7, 2015·The British Journal of Nutrition·Jiguo ZhangBing Zhang
Oct 1, 2015·Archives of Endocrinology and Metabolism·Rennan de Oliveira CaminhottoRogério Antonio Laurato Sertié
Sep 21, 2017·Nutrients·Bettina Geidl-Flueck, Philipp A Gerber
Aug 12, 2003·The British Journal of Nutrition·Christina Koutsari, Labros S Sidossis
Aug 13, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Labros S Sidossis
Apr 3, 2012·Journal of Zhejiang University. Science. B·Fabrice TranchidaAbel Hiol
Sep 27, 2012·American Journal of Physiology. Endocrinology and Metabolism·Andrea S CornfordJeffrey F Horowitz
Aug 5, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Faidon Magkos, Labros S Sidossis
Jul 13, 2006·American Journal of Physiology. Endocrinology and Metabolism·Faidon MagkosBettina Mittendorfer
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Joseph T HickeyEric C Westman
Mar 14, 2014·Medicine and Science in Sports and Exercise·Justin R TromboldEdward F Coyle
Apr 15, 2010·Journal of Nutrition for the Elderly·Stefanos TyrovolasDemosthenes B Panagiotakos
Apr 3, 2018·Journal of Nutrition and Metabolism·Vincent J MillerJeff S Volek
Aug 1, 2020·Frontiers in Endocrinology·Lutgarda BozzettoAngela Albarosa Rivellese
Mar 6, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C R BarbosaL N Castilho
Sep 11, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Maria Maraki, Labros S Sidossis
Mar 9, 2007·The Proceedings of the Nutrition Society·Mary F F ChongKeith N Frayn

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.