PMID: 6409083Mar 15, 1983Paper

Mechanism of 3-phenylpyruvate-induced insulin release. Metabolic aspects

The Biochemical Journal
W J MalaisseJ Christophe

Abstract

1. The metabolism and metabolic effects of 3-phenylpyruvate were examined in rat pancreatic islets. 2. Islet homogenates catalysed transamination reactions between 3-phenylpyruvate and L-glutamate, L-leucine, L-norleucine or L-valine. 3-Phenylpyruvate failed to activate glutamate dehydrogenase. 3. 3-Phenylpyruvate rapidly entered into islet cells, was extensively converted into phenylalanine but slowly oxidized. 4. The conversion of phenylpyruvate into phenylalanine coincided with a fall in the content of several amino acids (especially glutamate and aspartate) in the islets and incubation medium, the accumulation of 2-oxoglutarate and a modest fall in the NH4+ production rate. 5. 3-Phenylpyruvate failed to affect 14CO2 output from islets prelabelled with [U-14C]palmitate, but augmented 14CO2 output from islets prelabelled or incubated with L-[U-14C]glutamine. 6. In the presence of L-glutamine, 3-phenylpyruvate augmented the ATP/ADP ratio and NAD(P)H islet content, and caused a rapid and sustained decrease in the outflow of radioactivity from islets prelabelled with [2-3H]adenosine. 7. These data support the view that the insulin-releasing capacity of 3-phenylpyruvate coincides with an increase in the catabolism of endogenous a...Continue Reading

Citations

Oct 15, 1984·European Journal of Biochemistry·A SenerW J Malaisse
May 18, 2016·Upsala Journal of Medical Sciences·Michael Welsh
Aug 31, 2016·Bioresource Technology·Yang SongJian Chen
Oct 15, 1984·Experientia·A Sener, W J Malaisse
Oct 15, 1984·Experientia·L BestW J Malaisse
Jul 1, 1984·Cell Biochemistry and Function·R GomisW J Malaisse
Dec 2, 1985·FEBS Letters·A Sener, W J Malaisse
Jan 1, 1987·Journal of Inherited Metabolic Disease·I AntonozziR Dominici
Jul 1, 1983·Acta diabetologica latina·A SenerW J Malaisse
Aug 1, 1984·Journal of Endocrinological Investigation·P LebrunW J Malaisse
Jul 1, 1984·Molecular and Cellular Endocrinology·A SenerW J Malaisse
Sep 1, 1985·Archives of Biochemistry and Biophysics·M H GiroixW J Malaisse

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