Mechanism of action of antiplatelet drugs on decompression sickness in rats: a protective effect of anti-GPIIbIIIa therapy

Journal of Applied Physiology
Kate LambrechtsFrançois Guerrero

Abstract

Literature highlights the involvement of disseminated thrombosis in the pathophysiology of decompression sickness (DCS). We examined the effect of several antithrombotic treatments targeting various pathways on DCS outcome: acetyl salicylate, prasugrel, abciximab, and enoxaparin. Rats were randomly assigned to six groups. Groups 1 and 2 were a control nondiving group (C; n = 10) and a control diving group (CD; n = 30). Animals in Groups 3 to 6 were treated before hyperbaric exposure (HBE) with either prasugrel (n = 10), acetyl salicylate (n = 10), enoxaparin (n = 10), or abciximab (n = 10). Blood samples were taken for platelet factor 4 (PF4), thiobarbituric acid reactive substances (TBARS), and von Willebrand factor analysis. Onset of DCS symptoms and death were recorded during a 60-min observation period after HBE. Although we observed fewer outcomes of DCS in all treated groups compared with the CD, statistical significance was reached in abciximab only (20% vs. 73%, respectively, P = 0.007). We also observed significantly higher levels of plasmatic PF4 in abciximab (8.14 ± 1.40 ng/ml; P = 0.004) and enoxaparin groups (8.01 ± 0.80 ng/ml; P = 0.021) compared with the C group (6.45 ± 1.90 ng/ml) but not CD group (8.14 ± 1.40 n...Continue Reading

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Citations

Apr 24, 2016·Journal of Thrombosis and Thrombolysis·Peter Buzzacott, Andreas Mollerlokken
Apr 14, 2016·Proteomics. Clinical Applications·Jacky LautridouFrançois Guerrero
Jan 23, 2017·European Journal of Applied Physiology·Kate LambrechtsFrançois Guerrero
Apr 26, 2017·Proteomics. Clinical Applications·Jacky LautridouFrançois Guerrero
Jul 22, 2017·Medicine and Science in Sports and Exercise·Jacky LautridouFrançois Guerrero
Mar 17, 2018·Frontiers in Physiology·Aleksandra MazurFrançois Guerrero
Jan 16, 2016·Journal of Applied Physiology·Aleksandra MazurFrançois Guerrero
Jul 24, 2020·Journal of Applied Physiology·Jacky LautridouFrançois Guerrero

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