PMID: 6166184Mar 1, 1981Paper

Mechanism of action of antiviral hetarylhydrazones in vitro

Acta Virologica
M Tonew

Abstract

Three antiviral hetarylhydrazones showed a depression of 3H-uridine incorporation into RNA of FL cells as a consequence of inhibition of uridine transport into the cells. By eliminating the action of the compounds on transport processes with the prelabelling method, only one compound showed a nearly 50% reduction of cellular RNA synthesis during the whole incubation period, whereas the other two compounds had no influence during the first 6 hr. Under prelabelling conditions all three compounds completely inhibited the synthesis of Mengo virus RNA. One compound did not affect cellular DNA synthesis, but presumably depressed thymidine transport into the cells.

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