PMID: 376103May 1, 1979Paper

Mechanism of action of diet as a carcinogen

Cancer
J H Weisburger

Abstract

Stomach cancer in the United States has decreased over the last 50 years. It is still a major type of neoplasm in Japan, Eastern and Northern Europe, and parts of Latin America. Current concepts suggest that the reduction of gastric cancer in the U. S. stems from an increased consumption of foods with vitamin C on a year round basis, which is shown to antagonize the formation of putative gastric carcinogens. Risk factors for large bowel, breast, and prostate cancer are totally different from those for gastric cancer and thus are amenable to independent controls, with the goal of ultimately reducing the risk and preventing these major cancers in man. Current research aims to identify the nature of the mutagenic materials obtained during the frying of protein-containing foods. This process may be involved in the generation of carcinogens for cancer of the colon, breast, and prostate. Cancer of the colon is subject to somewhat different controlling elements than cancer of the breast because of the nature of the cell kinetics governing these tissues. Thus, the mechanism of action of diet involves lifestyle. The type, quality, and mode of cooking of food, particularly, play important roles in the etiology of the main human cancers i...Continue Reading

References

Apr 1, 1977·Food and Cosmetics Toxicology·H MarquardtJ H Weisburger
Jul 12, 1975·Lancet·P CorreaM Archer
Jul 22, 1978·Lancet·H C Trowell
Mar 30, 1978·Annals of the New York Academy of Sciences·L Tobian
May 1, 1979·Cancer·E L Wynder
Dec 1, 1977·Preventive Medicine·E L Wynder, T Hirayama
Feb 1, 1978·Journal of the National Cancer Institute·S R TannenbaumW W Bishop
Jan 1, 1978·Journal of Toxicology and Environmental Health·A J VithayathilP Madyastha
Nov 23, 1976·The American Journal of Cardiology·G R Meneely, H D Battarbee
Sep 1, 1977·Journal of the National Cancer Institute·H McGregorG W Beebe
Jan 1, 1977·Bioinorganic Chemistry·G N Schrauzer
Nov 1, 1977·Cancer·J H WeisburgerE L Wynder
Sep 30, 1975·Annals of the New York Academy of Sciences·R Raineri, J H Weisburger
Sep 30, 1975·Annals of the New York Academy of Sciences·S S Mirvish
Dec 1, 1975·Food and Cosmetics Toxicology·E F Binkerd, O E Kolari
Feb 1, 1976·Journal of the National Cancer Institute·W HaenszelM Segi
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R Goth, M F Rajewsky
Jan 1, 1973·Journal of the National Cancer Institute·B MacMahonJ Brown

❮ Previous
Next ❯

Citations

Mar 1, 1984·Mutation Research·E OvervikJ A Gustafsson
Aug 1, 1986·Mutation Research·T KinouchiY Ohnishi
Jan 21, 1982·Journal of Theoretical Biology·M M Melicow
May 1, 1980·Preventive Medicine·J H WeisburgerG Williams
Jul 1, 1980·Preventive Medicine·S H Brammer, R L DeFelice
Mar 1, 1980·Preventive Medicine·J H WeisburgerB Lewis
Jun 15, 1986·International Journal of Cancer. Journal International Du Cancer·W JedrychowskiJ Rachtan
Sep 1, 1979·Cancer Letters·N E Spingarn, J H Weisburger
Jan 1, 1989·Nutrition and Cancer·M K HargreavesA Gamshadzahi
Jan 1, 1992·Critical Reviews in Food Science and Nutrition·R J Scheuplein
Jan 1, 1981·The Proceedings of the Nutrition Society·J V Joossens, J Geboers
May 1, 1979·Cancer·E L Wynder
Jan 1, 1981·Nutrition and Cancer·J V Joossens, J Geboers
Jan 1, 1982·Nutrition and Cancer·B S Appleton, T C Campbell
Mar 1, 1981·Cancer·L D Lefall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.