PMID: 7009294Feb 1, 1981Paper

Mechanism of action of insulin and insulin analogues. A comparison of the hepatic and peripheral effects on glucose turnover of insulin, proinsulin and three insulin analogues modified at positions A1 and B29

Diabetologia
C V TompkinsP H Sönksen

Abstract

A [14C]-glucose tracer infusion method was used to compare the effects of insulin infusion on glucose metabolism with the effects of infusion of three semisynthetic modified insulins and of proinsulin. Insulin produced hypoglycaemia in the anaesthetised dog by decreasing hepatic glucose production and increasing peripheral glucose utilisation. Compensatory antihypoglycaemic mechanisms eventually modified these responses. A1, B29-Diacetyl insulin exerted an hypoglycaemic effect entirely by stimulation of peripheral glucose uptake. A1-B29 crosslinked insulins and proinsulin produced hypoglycaemia almost entirely by decreasing hepatic glucose production and had little effect on tissue uptake. These observations suggest that insulin analogues may have actions in vivo that are qualitatively different from those of native insulin and suggest that certain analogues have a predominant action on the liver. This has important therapeutic implications concerning the development of semisynthetic insulins for clinical use.

References

May 1, 1975·The American Journal of Physiology·P E HardingJ B Field
Jun 1, 1974·Diabetes·S E Fineberg, T J Merimee
Dec 1, 1970·The Journal of Clinical Endocrinology and Metabolism·J S Cheng, N Kalant
Mar 11, 1972·The American Journal of Physiology·B IssekutzI Borkow
Apr 1, 1971·Metabolism: Clinical and Experimental·J S Cowan, G Hetenyi
Mar 1, 1971·Acta diabetologica latina·G Hetenyi
Apr 1, 1969·Metabolism: Clinical and Experimental·J S CowanG A Wrenshall
May 1, 1966·Metabolism: Clinical and Experimental·R E BolingerT T Kuske
Jan 1, 1967·Biochemistry·J Katz, A Dunn
Oct 1, 1956·The American Journal of Physiology·R STEELEN ALTSZULER
Sep 25, 1959·Annals of the New York Academy of Sciences·R STEELE
Feb 1, 1965·The American Journal of Physiology·R STEELER C DEBODO

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Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·T UchioS W Kim
Oct 6, 1997·Endocrinology and Metabolism Clinics of North America·M R Burge, D S Schade
May 1, 1988·Baillière's Clinical Endocrinology and Metabolism·D A RobertsonM Nattrass
Nov 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·A VølundJ Schlichtkrull
Jun 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·S V GeldingD G Johnston
Apr 1, 2008·British Journal of Pharmacology·R I G Holt, P H Sönksen
Mar 19, 2016·Nature Reviews. Drug Discovery·Alexander N ZaykovRichard D DiMarchi
Apr 1, 1987·Diabetes/metabolism Reviews·E Ferrannini, C Cobelli
Aug 19, 2015·Molecular and Cellular Endocrinology·Daniel H Bedinger, Sean H Adams
May 5, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Francisco J Gómez-PérezJuan A Rull
Feb 1, 1987·The American Journal of Physiology·M Lavelle-JonesA R Moossa
Feb 1, 1987·The American Journal of Physiology·Z ChapJ B Field
Jul 1, 1992·The American Journal of Physiology·S N DavisK G Alberti
Nov 11, 1983·The American Journal of Physiology·D P FiglewiczG J Taborsky
Jul 26, 2019·ACS Chemical Biology·Florence M BrunelRichard D DiMarchi

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