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Mechanism of action of Mg2+ and Zn2+ on rat placental alkaline phosphatase. I. Studies on the soluble Zn2+ and Mg2+ alkaline phosphatases

Canadian Journal of Biochemistry

Oct 1, 1975

C J PetitclercN Brière

PMID: 1142

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Abstract

Rat placental alkaline phosphatase (EC 3.1.3.1), a dimer of 135,000 daltons, is strongly activated by Mg2+. However, Zn2+ has to be present on the apoenzyme to obtain this activation. Mg2+ alone is unable to reconstitute functional active sites. Excess Zn2+ which competes for the Mg2+ s...read more

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Soluble
Inorganic phosphate
Phosphate ion
Entire Placenta
Orthophosphate
Alkaline Phosphatase Activity
Metal Antagonists
Alkaline Phosphatase Measurement
Acids
Covalent Interaction
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  • Mechanism of action of Mg2+ and Zn2+ on rat placental alkaline phosphatase. I. Studies on the soluble Zn2+ and Mg2+ alkaline phosphatases

    Canadian Journal of Biochemistry

    Oct 1, 1975

    C J PetitclercN Brière

    PMID: 1142

    DOI:

    Abstract

    Rat placental alkaline phosphatase (EC 3.1.3.1), a dimer of 135,000 daltons, is strongly activated by Mg2+. However, Zn2+ has to be present on the apoenzyme to obtain this activation. Mg2+ alone is unable to reconstitute functional active sites. Excess Zn2+ which competes for the Mg2+ s...read more

    Mentioned in this Paper

    Soluble
    Inorganic phosphate
    Phosphate ion
    Entire Placenta
    Orthophosphate

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